Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …

The underlying cause of aging remains one of the central mysteries of biology. Recent
studies in several different systems suggest that not only may the rate of aging be modified …

Cellular senescence permanently arrests cell proliferation, often accompanied by a multi-
faceted senescence-associated secretory phenotype (SASP). Loss of mitochondrial function …

The aging process is associated with loss of muscle mass and strength and decline in
physical functioning. The term sarcopenia is primarily defined as low level of muscle mass …

Cardiovascular disease (CVD) is the leading cause of death in the United States and aging
is a major risk factor for CVD development. One of the major age-related arterial phenotypes …

There are several pathologies, syndromes, and physiological processes in which autophagy
is involved. This process of self‐digestion that cells trigger as a survival mechanism is …

Skeletal muscle health is dependent on the optimal function of its mitochondria. With
advancing age, decrements in numerous mitochondrial variables are evident in muscle. Part …

Micro-vesicles can be released by different cell types and operate as 'safe containers'
mediating inter-cellular communication. In this work we investigated whether cultured …

Background Aging results in a progressive loss of skeletal muscle, a condition known as
sarcopenia. Mitochondrial DNA (mtDNA) mutations accumulate with aging in skeletal …

Aging is a degenerative process that is associated with progressive accumulation of
deleterious changes with time, reduction of physiological function and increase in the …