Examining the Role of a Functional Deficiency of Iron in Lysosomal Storage Disorders with Translational Relevance to Alzheimer's Disease

SM LeVine - Cells, 2023 - mdpi.com
The recently presented Azalea Hypothesis for Alzheimer's disease asserts that iron
becomes sequestered, leading to a functional iron deficiency that contributes to …

The role of ferroptosis-related non-coding RNA in liver fibrosis

G Zhang, K Wu, X Jiang, Y Gao, D Ding… - Frontiers in Cell and …, 2024 - frontiersin.org
Liver fibrosis represents a reversible pathophysiological process, caused by chronic
inflammation stemming from hepatocyte damage. It delineates the initial stage in the …

Cr (VI) induces ferroptosis in DF-1 cells by simultaneously perturbing iron homeostasis of ferritinophagy and mitophagy

K Song, X Liu, H Xu, M Li, Q Zheng, C Qi… - Science of The Total …, 2024 - Elsevier
Abstract Hexavalent chromium [Cr (VI)] is an environmental pollutant known for its strong
oxidizing and carcinogenic effects. However, its potential to induce ferroptosis in poultry …

Iron homeostasis, recycling and vulnerability in the stressed kidney: A neglected dimension of iron‐deficient heart failure

M Packer - European Journal of Heart Failure, 2024 - Wiley Online Library
The available evidence suggests that the kidney may contribute importantly to the
development of an iron deficiency state in patients with heart failure and may be injured by …

Iron Overload in Brain: Transport Mismatches, Microbleeding Events, and How Nanochelating Therapies May Counteract Their Effects

E Ficiarà, I Stura, A Vernone, F Silvagno… - International Journal of …, 2024 - mdpi.com
Iron overload in many brain regions is a common feature of aging and most
neurodegenerative diseases. In this review, the causes, mechanisms, mathematical models …

Structure and function of trans-membrane proteins

I Roterman, M Brylinski, F Polticelli… - Frontiers in …, 2024 - frontiersin.org
Proteins perform the majority of essential biological functions. They can be simplified into 3
main structural classes: globular (ie, cytosolic), trans-membrane (ie, embedded in lipid …

Manganese transporter SLC30A10 and iron transporters SLC40A1 and SLC11A2 impact dietary manganese absorption

M Prajapati, JZ Zhang, GS Chong, L Chiu… - …, 2024 - pmc.ncbi.nlm.nih.gov
SLC30A10 deficiency is a disease of severe manganese excess attributed to loss of
SLC30A10-dependent manganese excretion via the gastrointestinal tract. Patients develop …

SLC25 family with energy metabolism and immunity in malignant tumors

G Zhang, N Wang, S Ma, Z Wei, P Tao, H Cai - Oncologie, 2024 - degruyter.com
Abstract Solute Carrier Family 25 (SLC25) is the largest family of mitochondrial membrane
proteins in the human body, consisting of 53 members. Mitochondrial phosphate carriers …

Investigating the ferroportin-ferroxidase system

M Amadei - 2024 - iris.uniroma1.it
Iron is essential for various pivotal biological processes, such as oxygen transport, DNA
synthesis, and ATP production. In humans, dysregulation in iron metabolism leads to severe …