The last decade has seen significant developments in cell therapies, based on permanently
differentiated, reprogrammed or engineered stem cells, for tendon injuries and degenerative …

Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs), and induced PSCs
(iPSCs) are able to self-renew and differentiate into a multitude of specialized cellular …

Nonsense‐mediated mRNA decay (NMD) is a post‐transcriptional mechanism that targets
aberrant transcripts and regulates the cellular RNA reservoir. Genetic modulation in …

Diabetes mellitus is the most prevailing disease with progressive incidence worldwide. To
date, the pathogenesis of diabetes is far to be understood, and there is no permanent …

Germ cell tumors (GCTs) represent a diverse group of tumors presumably originating from
(early fetal) developing germ cells. Most frequent are the testicular germ cell cancers …

Summary miR-302/367 is the most abundant miRNA cluster in human embryonic stem cells
(hESCs) and can promote somatic cell reprogramming. However, its role in hESCs remains …

Understanding the mechanisms regulating cell cycle, proliferation and potency of pluripotent
stem cells guarantees their safe use in the clinic. Embryonic stem cells (ESCs) present a fast …

ROS are frequently associated with deleterious effects caused by oxidative stress. Despite
the harmful effects of non-specific oxidation, ROS also function as signal transduction …

Cells initiate fate decisions during G1 phase by converting extracellular signals into
distinctive cell cycle kinetics. The DNA replication timing is determined in G1 phase; …

A growing number of researches suggest that microRNAs (miRNAs) as oncogene or tumor
suppressor genes play a fundamental role in various kinds of cancers. Among them, miR-24 …