Phototoxicity in live fluorescence microscopy, and how to avoid it
Phototoxicity frequently occurs during live fluorescence microscopy, and its consequences
are often underestimated. Damage to cellular macromolecules upon excitation light …
are often underestimated. Damage to cellular macromolecules upon excitation light …
Synaptic memory and CaMKII
RA Nicoll, H Schulman - Physiological reviews, 2023 - journals.physiology.org
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …
were discovered within a decade of each other and have been inextricably intertwined ever …
[HTML][HTML] Fast and sensitive GCaMP calcium indicators for imaging neural populations
Calcium imaging with protein-based indicators, is widely used to follow neural activity in
intact nervous systems, but current protein sensors report neural activity at timescales much …
intact nervous systems, but current protein sensors report neural activity at timescales much …
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction
Alpha-synuclein is known to bind to small unilamellar vesicles (SUVs) via its N terminus,
which forms an amphipathic alpha-helix upon membrane interaction. Here we show that …
which forms an amphipathic alpha-helix upon membrane interaction. Here we show that …
The calcium sensor synaptotagmin 7 is required for synaptic facilitation
It has been known for more than 70 years that synaptic strength is dynamically regulated in a
use-dependent manner. At synapses with a low initial release probability, closely spaced …
use-dependent manner. At synapses with a low initial release probability, closely spaced …
The calpain system
DE Goll, VF Thompson, H Li, WEI Wei… - Physiological …, 2003 - journals.physiology.org
Abstract Goll, Darrel E., Valery F. Thompson, Hongqi Li, Wei Wei, and Jinyang Cong. The
Calpain System. Physiol Rev 83: 731–801, 2003; 10.1152/physrev. 00029.2002.—The …
Calpain System. Physiol Rev 83: 731–801, 2003; 10.1152/physrev. 00029.2002.—The …
A comparison of neuronal population dynamics measured with calcium imaging and electrophysiology
Calcium imaging with fluorescent protein sensors is widely used to record activity in
neuronal populations. The transform between neural activity and calcium-related …
neuronal populations. The transform between neural activity and calcium-related …
Multiple dynamic representations in the motor cortex during sensorimotor learning
The mechanisms linking sensation and action during learning are poorly understood. Layer
2/3 neurons in the motor cortex might participate in sensorimotor integration and learning; …
2/3 neurons in the motor cortex might participate in sensorimotor integration and learning; …
Structure and function of dendritic spines
EA Nimchinsky, BL Sabatini… - Annual review of …, 2002 - annualreviews.org
▪ Abstract Spines are neuronal protrusions, each of which receives input typically from one
excitatory synapse. They contain neurotransmitter receptors, organelles, and signaling …
excitatory synapse. They contain neurotransmitter receptors, organelles, and signaling …
Principles of two-photon excitation microscopy and its applications to neuroscience
The brain is complex and dynamic. The spatial scales of interest to the neurobiologist range
from individual synapses (∼ 1 μm) to neural circuits (centimeters); the timescales range from …
from individual synapses (∼ 1 μm) to neural circuits (centimeters); the timescales range from …