The voltage-gated sodium channel α-subunit genes comprise a highly conserved gene
family. Mutations of three of these genes, SCN1A, SCN2A and SCN8A, are responsible for a …

Axons are generally considered as reliable transmission cables in which stable propagation
occurs once an action potential is generated. Axon dysfunction occupies a central position in …

Dorsal root ganglion (DRG) sensory neuron subtypes defined by their in vivo properties
display distinct intrinsic electrical properties. We used bulk RNA sequencing of genetically …

Voltage-gated sodium channel Nav1. 6 plays a crucial role in neuronal firing in the central
nervous system (CNS). Aberrant function of Nav1. 6 may lead to epilepsy and other …

In neurons, the axon initial segment (AIS) is a specialized region near the start of the axon
that is the site of action potential initiation,,,,,. The precise location of the AIS varies across …

The distal end of the axon initial segment (AIS) is the preferred site for action potential
initiation in cortical pyramidal neurons because of its high Na+ channel density. However, it …

The axon initial segment (AIS) is a specialized membrane region in the axon of neurons
where action potentials are initiated. Crucial to the function of the AIS is the presence of …

Voltage-gated sodium channels initiate action potentials in nerve, skeletal muscle, and other
electrically excitable cells. Mutations in them cause a wide range of diseases. These …

Cortical spreading depression (CSD), a wave of depolarization followed by depression of
cortical activity, is a pathophysiological process implicated in migraine with aura and various …

The action potential generally begins in the axon initial segment (AIS), a principle confirmed
by 60 years of research; however, the most recent advances have shown that a very rich …