Focusing on the recent literature (since 2000), this review outlines the main synthetic
approaches for the preparation of 5′-mono-, 5′-di-, and 5′-triphosphorylated …

In this review, our recent advances in the development of nucleoside di-and nucleoside
triphosphate prodrugs is summarized. Previously, we had developed a successful …

We report on the synthesis and evaluation of three different nucleotide prodrug systems:(i)
nucleoside triphosphate analogues in which the γ-phosph (on) ate has two different …

The metabolic conversion of nucleoside analogues into their triphosphates often proceeds
insufficiently. Rate‐limitations can be at the mono‐, but also at the di‐and triphosphorylation …

We disclose a study on nucleoside triphosphate (NTP) analogues in which the γ-phosphate
is covalently modified by two different biodegradable masking units and d4T as nucleoside …

A procedure for the synthesis of nucleoside polyphosphates and their conjugates using
sulfonylimidazolium salts as key reagents is described. The procedure is rapid and high …

The fluorine atom plays an important role in medicinal chemistry because fluorine
substitution has a strong impact on the physical, chemical, and biological properties of …

Oligophosphates play essential roles in biochemistry, and considerable research has been
directed toward the synthesis of both naturally occurring oligophosphates and their synthetic …

Nucleoside reverse transcriptase inhibitors (NRTIs) are widely used as antiviral and
anticancer agents, although they require intracellular phosphorylation into their antivirally …

Phosphoanhydrides (P‐anhydrides) are ubiquitously occurring modifications in nature.
Nucleotides and their conjugates, for example, are among the most important building …