Pharmacological agents used to treat or manage diseases can modify the level of heat strain
experienced by chronically ill and elderly patients via different mechanistic pathways …

Transient receptor potential vanilloid 4 (TRPV4) channels exist in the endothelial cells of
cutaneous blood vessels and the secretory cells of eccrine sweat glands. We assessed if …

Acetylcholine released from cholinergic nerves is involved in heat loss responses of
cutaneous vasodilation and sweating. K+ channels are thought to play a role in regulating …

While the mechanisms underlying the control of cutaneous vasodilation have been
extensively studied, there remains a lack of understanding of the different factors that may …

Acetylcholine released from cholinergic nerves is a key neurotransmitter contributing to heat
stress-induced cutaneous vasodilation and sweating. Given that sympathetic cholinergic …

Key points In humans in vivo, the mechanisms behind ATP‐mediated cutaneous
vasodilatation along with whether and how ATP increases sweating remains uncertain …

New Findings What is the central question of this study? Do transmembrane member 16A
(TMEM16A) blockers modulate the activation of heat loss responses of sweating and …

Purpose Sweat glands and cutaneous vessels possess growth hormone (GH) and insulin-
like growth factor 1 (IGF-1) receptors. Here, we assessed if exercise increases GH and IGF-1 …

We evaluated the influence of K+ channels (ie, Ca2+-activated K+ (KCa), ATP-sensitive K+
(KATP), and voltage-gated K+ (KV) channels) and key enzymes (nitric oxide synthase (NOS) …

Iontophoretic transdermal administration of N G-nitro-l-arginine methyl ester hydrochloride [l-
NAME, a nitric oxide synthase (NOS) inhibitor] has been used as a non-invasive evaluation …