Musculoskeletal injuries and disorders are the leading cause of physical disability
worldwide and a considerable socioeconomic burden. The lack of effective therapies has …

In a growing multidrug-resistant environMent, the identification of potential new drug
candidates with an acceptable safety profile is a substantial crux in pharmaceutical …

Simple Summary The intrauterine period plays a major role in skeletal muscle development
and metabolism, including the formation of muscle fibers and adipose and connective tissue …

ABSTRACT According to the World Health Organization (WHO), cancer is the second-
highest cause of mortality worldwide, killing nearly 9.6 million people annually. Despite the …

Experimental cell therapies for skeletal muscle conditions have shown little success,
primarily because they use committed myogenic progenitors rather than true muscle stem …

Massive rotator cuff (RC) tendon tears are associated with progressive fibro-adipogenesis
and muscle atrophy that altogether cause shoulder muscle wasting. Platelet derived growth …

Peripheral nerve injury denervates muscle, resulting in muscle paralysis and atrophy. This is
reversible if timely muscle reinnervation occurs. With delayed reinnervation, the muscle's …

Lysine methylation signaling is well studied for its key roles in the regulation of transcription
states through modifications on histone proteins. While histone lysine methylation has been …

Engineering of biomimetic tissue implants provides an opportunity for repairing volumetric
muscle loss (VML), beyond a tissue's innate repair capacity. Here, we present thick …

Transcription factor-based cellular reprogramming provides an attractive approach to
produce desired cell types for regenerative medicine purposes. Such cellular conversions …