Phthalates are esters of phthalic acid which are used in cosmetics and other daily personal
care products. They are also used in polyvinyl chloride (PVC) plastics to increase durability …

Genetic and epigenetic mechanisms regulate the transition from the totipotent zygote to
pluripotent primitive ectoderm cells in the inner cell mass of mouse blastocysts. These …

Germ cell fate in mice is induced in pluripotent epiblast cells in response to signals from
extraembryonic tissues. The specification of approximately 40 founder primordial germ cells …

A unique feature of the germ cell lineage is the generation of totipotency. A critical event in
this context is DNA demethylation and the erasure of parental imprints in mouse primordial …

Blimp1, a transcriptional repressor, has a crucial role in the specification of primordial germ
cells (PGCs) in mice at embryonic day 7.5 (E7. 5),. This SET–PR domain protein can form …

Cancer, as one of the non-communicable diseases, remains one of the leading causes of
death around the world. Recently, epigenetic changes in DNA methylation patterns at CpG …

Abstract The DNA base 5-hydroxymethylcytosine (5hmC) is produced by enzymatic
oxidation of 5-methylcytosine (5mC) by 5mC oxidases (the Tet proteins). Since 5hmC is …

The acquisition and maintenance of cell fate are essential for metazoan growth and
development. A strict coordination between genetic and epigenetic programs regulates cell …

Epigenetic mechanisms play an essential role in the germline and imprinting cycle. Germ
cells show extensive epigenetic programming in preparation for the generation of the …

Embryonic development is regulated by both genetic and epigenetic mechanisms, with
nearly all DNA-templated processes influenced by chromatin architecture. Sequence …