Contrast-induced acute kidney injury (CI− AKI) is manifested by an abrupt decline in kidney
function as a consequence of intravascular exposure to contrast media. With the increased …

Background Colistin is a polymyxin antibiotic which has been used for treatment of Gram-
negative infections, but it was withdrawn due to its nephrotoxicity. However, colistin has …

Background Proximal tubules (PTs) are exposed to many exogenous and endogenous
nephrotoxins that pass through the glomerular filter. This includes many small molecules …

The recent understanding that hydrophobic β-lactams have greater affinity for organic anion
transporter-3 (OAT-3) of the proximal renal tubule could provide valuable insights for …

Background Antimicrobial resistance is on the rise. The use of redundant and inappropriate
antibiotics is contributing to recurrent infections and resistance. Newer antibiotics with more …

ABSTRACT Rationale & Objective Cilastatin is an inhibitor of drug metabolism in the
proximal tubule that demonstrates nephroprotective effects in animals. It has been used in …

Glaucoma is a neurodegenerative disease that causes blindness. In this study, we aimed to
evaluate the protective role of cilastatin (CIL), generally used in the treatment of …

The risk of vancomycin (VAN)-associated acute kidney injury (AKI) may be altered with
combination regimens. The specific AKI risk when VAN is combined with imipenem …

OBJECTIVE: By creating nephrotoxicity models with cisplatin, vancomycin, and gentamicin
in HK-2 (human renal proximal tubule cell) and HEK293T (human embryonic kidney …

The immunophilin FKBP51, the angiomotin AmotL2, and the scaffoldin IQGAP1 are
overexpressed in many types of cancer, with the highest increase in leucocytes from patients …