The pharmaceutical industry has been desperately searching for efficient drug discovery
methods. Organ-on-a-Chip, a cutting-edge technology that can emulate the physiological …

During embryonic morphogenesis, the heart undergoes a complex series of cellular
phenotypic maturations (eg, transition of myocytes from proliferative to quiescent or …

In some patients, COVID-19 can trigger neurological symptoms with unclear pathogenesis.
Here we describe a microphysiological system integrating alveolus and blood–brain barrier …

Friedreich's ataxia (FRDA) is an autosomal-recessive neurodegenerative and cardiac
disorder which occurs when transcription of the FXN gene is silenced due to an excessive …

In this study, we report static and perfused models of human myocardial-microvascular
interaction. In static culture, we observe distinct regulation of electrophysiology of human …

Cardiac fibrosis is a common pathology in cardiovascular diseases which are reported as
the leading cause of death globally. In recent decades, accumulating evidence has shown …

The creation of cardiac tissue models for preclinical testing is still a non-solved problem in
drug discovery, due to the limitations related to the in vitro replication of cardiac tissue …

Introduction: Historically, drug development and marketing failures have been experienced
by pharma organizations largely from insufficient human-predictability of biological data …

Despite the latest advances in cardiovascular biology and medicine, myocardial infarction
(MI) remains one of the major causes of deaths worldwide. While reperfusion of the …

Over the past decades, stem cell technology has revolutionalized medical biotechnology
due to the unlimited self-renewal ability and differentiation capacity of stem cells to generate …