Bisphosphonate-related osteonecrosis of the jaw: is pH the missing part in the pathogenesis puzzle?

S Otto, S Hafner, G Mast, T Tischer, E Volkmer… - Journal of Oral and …, 2010 - Elsevier
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a side effect of
bisphosphonate therapy, primarily diagnosed in patients with cancer and metastatic bone …

In vitro cytotoxicity of antiresorptive and antiangiogenic compounds on oral tissues contributing to MRONJ: systematic review

RH Guirguis, LP Tan, RM Hicks, A Hasan, TD Duong… - Biomolecules, 2023 - mdpi.com
Background: Invasive dental treatment in patients exposed to antiresorptive and
antiangiogenic drugs can cause medication-related osteonecrosis of the jaw (MRONJ) …

Tooth extraction in patients receiving oral or intravenous bisphosphonate administration: a trigger for BRONJ development?

S Otto, M Tröltzsch, V Jambrovic, S Panya… - Journal of Cranio …, 2015 - Elsevier
Introduction Scientific debate outlines tooth extraction as a potential trigger for the onset of
bisphosphonate-related osteonecrosis of the jaw (BRONJ). Therefore, the aim of this study …

Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a …

S Delanian, C Chatel, R Porcher, J Depondt… - International Journal of …, 2011 - Elsevier
PURPOSE: Osteoradionecrosis (ORN) is a nonhealing wound of the bone that is difficult to
manage. Combined treatment with pentoxifylline and vitamin E reduces radiation-induced …

A multicenter retrospective study of the risk factors associated with medication-related osteonecrosis of the jaw after tooth extraction in patients receiving oral …

T Hasegawa, A Kawakita, N Ueda, R Funahara… - Osteoporosis …, 2017 - Springer
Root amputation, extraction of a single tooth, bone loss or severe tooth mobility, and an
unclosed wound were significantly associated with increased risk of developing medication …

Osteonecrosis of the jaw: effect of bisphosphonate type, local concentration, and acidic milieu on the pathomechanism

S Otto, C Pautke, C Opelz, I Westphal, I Drosse… - Journal of Oral and …, 2010 - Elsevier
PURPOSE: Osteonecrosis of the jaw has been reported in patients receiving high doses of
intravenous nitrogen-containing bisphosphonates (N-BPs) because of malignant disease …

Bisphosphonates affect migration ability and cell viability of HUVEC, fibroblasts and osteoblasts in vitro

C Walter, A Pabst, T Ziebart, MO Klein… - Oral diseases, 2011 - Wiley Online Library
Oral Diseases (2011) 17, 194–199 Objectives: Bisphosphonate‐associated osteonecrosis of
the jaw (BP‐ONJ) is a side effect in patients being treated with bisphosphonates. The …

The influence of bisphosphonates on viability, migration, and apoptosis of human oral keratinocytes—in vitro study

AM Pabst, T Ziebart, FP Koch, KY Taylor… - Clinical oral …, 2012 - Springer
Bisphosphonate-associated osteonecrosis of the jaw (BP-ONJ) is one of the most often seen
side effects in patients treated with bisphosphonates, presenting clinically as a non-healing …

Management of bisphosphonate-related osteonecrosis of the jaw with a platelet-rich fibrin membrane: technical report

SS Soydan, S Uckan - Journal of oral and maxillofacial surgery, 2014 - Elsevier
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a challenging complication
resulting from the long-term application of bisphosphonates. In most cases, BRONJ occurs …

Bisphosphonate related osteonecrosis of the jaw: a minipig large animal model

C Pautke, K Kreutzer, J Weitz, M Knödler, D Münzel… - Bone, 2012 - Elsevier
Bisphosphonate related osteonecrosis of the jaw (BRONJ) is rare but potentially severe, and
the etiopathology and risk factors are poorly defined. To date, it has not been possible to …