Overexpression of ErbB2, a receptor-like tyrosine kinase, is shared by several types of
human carcinomas. In breast tumors the extent of overexpression has a prognostic value …

This past decade has witnessed the remarkable advances in the understanding of the role of
the erbB2 gene in cancers and the stunning progress in developing targeted therapies for …

Background Hormone-refractory prostate cancer remains hindered by inevitable
progression of resistance to first-line treatment with docetaxel. Recent studies suggest that …

The ErbB2-targeting antibody, trastuzumab (Herceptin), has remarkable therapeutic efficacy
in certain patients with ErbB2-overexpressing tumors. The overall trastuzumab response …

OBJECTIVE: To update the 1997 clinical practice guidelines for the use of tumor marker
tests in the prevention, screening, treatment, and surveillance of breast and colorectal …

Growth factors enable cells to escape irradiation-induced death (apoptosis). One important
family of growth factors share an epidermal growth factor motif, and all bind to ErbB …

Publisher Summary Carcinoma, cancer of epithelial cells, is a major cause of morbidity and
mortality. Clonal fixation and propagation of oncogenic genetic changes, sporadically …

The ErbB receptors and their cognate ligands that belong to the epidermal growth factor
(EGF) family of peptides are involved in the pathogenesis of different types of carcinomas. In …

By analyzing the gene expression profile between tumor cells and revertant counterparts
that have a suppressed malignant phenotype, we previously reported a significant down …

Breast cancer is the most common malignancy in women in the United States in the year
2000. The proto-oncogene Her-2/neu (c-erb-B2) has become an increasingly important …