The Keap1‐Nrf2 system: a mediator between oxidative stress and aging

C Yu, JH Xiao - Oxidative Medicine and Cellular Longevity, 2021 - Wiley Online Library
Oxidative stress, a term that describes the imbalance between oxidants and antioxidants,
leads to the disruption of redox signals and causes molecular damage. Increased oxidative …

Neuroprotective effects of coffee bioactive compounds: a review

K Socała, A Szopa, A Serefko, E Poleszak… - International journal of …, 2020 - mdpi.com
Coffee is one of the most widely consumed beverages worldwide. It is usually identified as a
stimulant because of a high content of caffeine. However, caffeine is not the only coffee …

Propolis extract and its bioactive compounds—From traditional to modern extraction technologies

J Šuran, I Cepanec, T Mašek, B Radić, S Radić… - Molecules, 2021 - mdpi.com
Propolis is a honeybee product known for its antioxidant, anti-inflammatory, anticancer, and
antimicrobial effects. It is rich in bioactive molecules whose content varies depending on the …

Autophagy and apoptosis cascade: which is more prominent in neuronal death?

R Gupta, RK Ambasta, P Kumar - Cellular and molecular life sciences, 2021 - Springer
Autophagy and apoptosis are two crucial self-destructive processes that maintain cellular
homeostasis, which are characterized by their morphology and regulated through signal …

Natural products and their bioactive compounds: neuroprotective potentials against neurodegenerative diseases

NS Mohd Sairazi… - … Based Complementary and …, 2020 - Wiley Online Library
In recent years, natural products, which originate from plants, animals, and fungi, together
with their bioactive compounds have been intensively explored and studied for their …

Multipronged diagnostic and therapeutic strategies for Alzheimer's disease

M Ramesh, T Govindaraju - Chemical science, 2022 - pubs.rsc.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and a major
contributor to dementia cases worldwide. AD is clinically characterized by learning, memory …

Transcription factor NRF2 as a promising therapeutic target for Alzheimer's disease

Z Qu, J Sun, W Zhang, J Yu, C Zhuang - Free Radical Biology and …, 2020 - Elsevier
Oxidative stress is considered as one of the pathogenesis of Alzheimer's disease (AD) and
plays an important role in the occurrence and development of AD. Nuclear factor erythroid 2 …

Neuroprotective effects of anthocyanins and its major component cyanidin-3-O-glucoside (C3G) in the central nervous system: An outlined review

J Zhang, J Wu, F Liu, L Tong, Z Chen, J Chen… - European journal of …, 2019 - Elsevier
Anthocyanins, a class of water soluble flavonoids extracted from plants like berries and
soybean seed, have been shown to display obvious anti-oxidative, anti-inflammatory, and …

Caffeic acid phenethyl ester suppresses oxidative stress and regulates M1/M2 microglia polarization via Sirt6/Nrf2 pathway to mitigate cognitive impairment in aged …

Y Wang, Z Cai, G Zhan, X Li, S Li, X Wang, S Li, A Luo - Antioxidants, 2023 - mdpi.com
Postoperative cognitive dysfunction (POCD) is a severe neurological complication after
anesthesia and surgery. However, there is still a lack of effective clinical pharmacotherapy …

Hybrid molecules based on caffeic acid as potential therapeutics: A focused review

X Zhao, Z Liu, H Liu, J Guo, S Long - European Journal of Medicinal …, 2022 - Elsevier
Caffeic acid-based compounds possess a high degree of structural diversity and show a
variety of pharmacological properties, providing a useful framework for the discovery of new …