SE Davis, L Zabotka, RJ Desai, SV Wang, JC Maro… - Drug Safety, 2023 - Springer
Introduction Pharmacovigilance programs protect patient health and safety by identifying adverse event signals through postmarketing surveillance of claims data and spontaneous …
Discovering novel uses for existing drugs, through drug repurposing, can reduce the time, costs, and risk of failure associated with new drug development. However, prioritizing drug …
W Hu, W Zhang, Y Zhou, Y Luo, X Sun… - Journal of Chemical …, 2023 - ACS Publications
Drug–drug interactions (DDIs) are a major concern in clinical practice and have been recognized as one of the key threats to public health. To address such a critical threat, many …
JA Pacheco, LV Rasmussen, K Wiley Jr, TN Person… - Scientific reports, 2023 - nature.com
Abstract The electronic Medical Records and Genomics (eMERGE) Network assessed the feasibility of deploying portable phenotype rule-based algorithms with natural language …
D Voora, J Baye, A McDermaid… - Clinical …, 2022 - Wiley Online Library
The SLCO1B1 genotype is known to influence patient adherence to statin therapy, in part by increasing the risk for statin‐associated musculoskeletal symptoms (SAMSs). The …
Introduction Phenotyping algorithms enable the interpretation of complex health data and definition of clinically relevant phenotypes; they have become crucial in biomedical …
J Zhu, Y Liu, Y Zhang, Z Chen… - IEEE Transactions on …, 2022 - ieeexplore.ieee.org
Adverse drug–drug interaction (ADDI) causes harmful injuries and accidental deaths in patients, posing as a significant life-threatening issue in public health. Early prediction of …
The field of immunogenomics has the opportunity for accelerated genetic discovery aided by the maturation of electronic health records (EHRs) linked to DNA biobanks. Novel analysis …
C Georgantas, J Banus, R Hullin… - PACIFIC SYMPOSIUM …, 2023 - World Scientific
Drug repurposing (DR) intends to identify new uses for approved medications outside their original indication. Computational methods for finding DR candidates usually rely on prior …