Recent advances in polycaprolactones for anticancer drug delivery

A Bhadran, T Shah, GK Babanyinah, H Polara… - Pharmaceutics, 2023 - mdpi.com
Poly (ε-Caprolactone) s are biodegradable and biocompatible polyesters that have gained
considerable attention for drug delivery applications due to their slow degradation and ease …

Polycaprolactone: a biodegradable polymer with its application in the field of self-assembly study

P Mandal, R Shunmugam - Journal of Macromolecular Science …, 2020 - Taylor & Francis
Synthetic polyesters have created a considerable attraction among the researchers over a
few decades. Among them, polycaprolactone (PCL) is of great interest since the 1970s …

Structural engineering of star block biodegradable polymer unimolecular micelles for drug delivery in cancer cells

U Pranav, M Malhotra, S Pathan… - … Biomaterials Science & …, 2022 - ACS Publications
The present investigation reports the structural engineering of biodegradable star block
polycaprolactone (PCL) to tailor-make aggregated micelles and unimolecular micelles to …

Maleimide functionalized polycaprolactone micelles for glutathione quenching and doxorubicin delivery

GK Babanyinah, A Bhadran, H Polara, H Wang… - Chemical …, 2024 - pubs.rsc.org
High glutathione production is known to be one of the defense mechanisms by which many
cancer cells survive elevated oxidative stress. By explicitly targeting glutathione in these …

Melt Polycondensation Strategy for Amide-Functionalized l-Aspartic Acid Amphiphilic Polyester Nano-assemblies and Enzyme-Responsive Drug Delivery in Cancer …

M Khuddus, M Jayakannan - Biomacromolecules, 2023 - ACS Publications
Aliphatic polyesters are intrinsically enzymatic-biodegradable, and there is ever-increasing
demand for safe and smart next-generation biomaterials including drug delivery nano …

Thermo/pH dual-stimuli-responsive drug delivery for chemo-/photothermal therapy monitored by cell imaging

Y Shu, R Song, A Zheng, J Huang, M Chen, J Wang - Talanta, 2018 - Elsevier
A thermo/pH dual-stimuli-responsive drug delivery system (DDS) based on polymer coated
mesoporous silica nanostructures (MSNs) is developed for facilitating chemotherapy and …

Versatile types of hydroxyl-rich polycationic systems via O-heterocyclic ring-opening reactions: From strategic design to nucleic acid delivery applications

FJ Xu - Progress in Polymer Science, 2018 - Elsevier
Safe and effective vectors play an important role in nucleic acid delivery processes. Ring-
opening reactions are quite often used to produce biomaterials with various functions and …

Theranostic FRET gate to visualize and quantify bacterial membrane breaching

R Ghosh, M Jayakannan - Biomacromolecules, 2023 - ACS Publications
Designing new antimicrobial-cum-probes to study real-time bacterial membrane breaching
and concurrently developing inquisitorial image-based analytical tools is essential for the …

Development of l-Tyrosine-Based Enzyme-Responsive Amphiphilic Poly(ester-urethane) Nanocarriers for Multiple Drug Delivery to Cancer Cells

R Aluri, M Jayakannan - Biomacromolecules, 2017 - ACS Publications
New classes of enzymatic-biodegradable amphiphilic poly (ester-urethane) s were designed
and developed from l-tyrosine amino acid resources and their self-assembled nanoparticles …

Zwitterionic Strategy to Stabilize Self‐Immolative Polymer Nanoarchitecture under Physiological pH for Drug Delivery In Vitro and In Vivo

S Pathan, M Jayakannan - Advanced Healthcare Materials, 2024 - Wiley Online Library
The major bottleneck in using polymer nanovectors for biomedical application, particularly
those based on self‐immolative poly (amino ester)(PAE), lies in their uncontrolled …