Signaling pathways and therapeutic interventions in gastric cancer

ZN Lei, QX Teng, Q Tian, W Chen, Y Xie… - Signal transduction and …, 2022 - nature.com
Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

Metastasis and MAPK pathways

M Kciuk, A Gielecińska, A Budzinska… - International journal of …, 2022 - mdpi.com
Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is
limited due to the metastasis of cells to distant locations of the body through the blood and …

TGF‑β1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis

Z Ye, Y Hu - International journal of molecular …, 2021 - spandidos-publications.com
Idiopathic pulmonary fibrosis (IPF) is a worldwide disease characterized by the chronic and
irreversible decline of lung function. Currently, there is no drug to successfully treat the …

Long non-coding RNA in gastric cancer: mechanisms and clinical implications for drug resistance

Y Liu, X Ao, Y Wang, X Li, J Wang - Frontiers in oncology, 2022 - frontiersin.org
Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide, with high
recurrence and mortality rate. Chemotherapy, including 5-fluorouracil (5-FU), adriamycin …

[HTML][HTML] Quercetin exerts anti-inflammatory effects via inhibiting tumor necrosis factor-α-induced matrix metalloproteinase-9 expression in normal human gastric …

HL Hsieh, MC Yu, LC Cheng, MY Chu… - World Journal of …, 2022 - ncbi.nlm.nih.gov
BACKGROUND Gastric injury is the most common digestive system disease worldwide and
involves inflammation, which can lead to gastric ulcer or gastric cancer (GC). Matrix …

STAT3 pathway in gastric cancer: signaling, therapeutic targeting and future prospects

M Ashrafizadeh, A Zarrabi, S Orouei, V Zarrin… - Biology, 2020 - mdpi.com
Molecular signaling pathways play a significant role in the regulation of biological
mechanisms, and their abnormal expression can provide the conditions for cancer …

Mechanisms of action and clinical implications of MicroRNAs in the drug resistance of gastric cancer

Y Liu, X Ao, G Ji, Y Zhang, W Yu, J Wang - Frontiers in oncology, 2021 - frontiersin.org
Gastric cancer (GC) is one of the most common malignant tumors of digestive systems
worldwide, with high recurrence and mortality. Chemotherapy is still the standard treatment …

Circadian disruption: from mouse models to molecular mechanisms and cancer therapeutic targets

Y Wang, H Guo, F He - Cancer and Metastasis Reviews, 2023 - Springer
The circadian clock is a timekeeping system for numerous biological rhythms that contribute
to the regulation of numerous homeostatic processes in humans. Disruption of circadian …

Epstein-Barr virus-encoded miR-BART11-3p modulates the DUSP6-MAPK axis to promote gastric cancer cell proliferation and metastasis

M Xu, J Lin, S Yang, J Yao, M Chen, J Feng… - Journal of …, 2023 - Am Soc Microbiol
ABSTRACT Epstein-Barr virus (EBV)-encoded miRNAs within the BamHI-A rightward
transcript (BART) region are abundantly expressed in EBV-associated gastric cancer …

The signaling pathways and targets of natural products from traditional Chinese medicine treating gastric cancer provide new candidate therapeutic strategies

Y Liao, Y Gui, Q Li, J An, D Wang - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Gastric cancer (GC) is one of the severe malignancies with high incidence and mortality,
especially in Eastern Asian countries. Significant advancements have been made in …