MicroRNAs (miRNAs) are short non-coding RNAs that regulate the expression of protein
coding genes of viruses and eukaryotes at the post-transcriptional level. The eukaryotic …

Gene expression regulation is a critical question in host-pathogen interactions, and RNAs
act as key players in this process. In this review, we focus on the mammalian RNA response …

Colorectal cancer (CRC) is a leading cause of cancer death and archetype for cancer as a
genetic disease. However, the mechanisms for genetic change and their interactions with …

Protein SUMOylation is a major post-translational modification essential for maintaining
cellular homeostasis. SUMOylation has long been associated with stress responses as a …

Bacteria evolved many strategies to survive and persist within host cells. Secretion of
bacterial effectors enables bacteria not only to enter the host cell but also to manipulate host …

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. The disease has
an acute and a chronic phase in which approximately 30% of the chronic patients suffer from …

Purpose High levels of heterogeneity and immunosuppression characterize the HCC
immune microenvironment (TME). Unfortunately, the majority of hepatocellular carcinoma …

The gut microbiota produces a wide variety of metabolites, which interact with intestinal cells
and contribute to host physiology. The effect of gut commensal bacteria on host protein …

Manipulation of host protein post-translational modifications (PTMs) is used by various
pathogens to interfere with host cell functions. Among these modifications, ubiquitin (UBI) …

The endolysosomal system comprises a dynamic constellation of vesicles working together
to sense and interpret environmental cues and facilitate homeostasis. Integrating …