Process of inflammation and complex interactions between immune and cancer cells within
tumor microenvironment are known to drive and shape the outcome of the neoplastic …

The development of an acidic tissue environment is a hallmark of a variety of inflammatory
processes and solid tumors. However, little attention has been paid so far to analyze the …

Many transient receptor potential (TRP) channels respond to diverse stimuli and
conditionally conduct small and large cations. Such functional plasticity is presumably …

Transient receptor potential (TRP) channels are cellular sensors for a wide spectrum of
physical and chemical stimuli. They are involved in the formation of sight, hearing, touch …

Capsaicin is the most predominant and naturally occurring alkamide found in Capsicum
fruits. Since its discovery in the 19th century, the therapeutic roles of capsaicin have been …

Diabetic neuropathic pain (DNP) is a common and devastating complication in patients with
diabetes. The mechanisms mediating DNP are not completely elucidated, and effective …

The factors that contribute to pain after nerve injury remain incompletely understood. Laser-
assisted in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) are common …

Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disorder often
characterized by severe neurodevelopmental abnormalities and neuro-retinal degeneration …

2 V. Buhé et al. non-sensitive skin, we first searched for these markers to detect possible
epidermal inflammation and a crucial role of PAR2. We also assessed the involvement of G …

A fundamental subdivision of nociceptive sensory neurons is named after their unique
sensitivity to capsaicin, the pungent ingredient in hot chili peppers: these are the capsaicin …