Many studies have shown that the efficacy and risk of side effects of drug treatment is
influenced by genetic variants. Evidence based guidelines are essential for implementing …

UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

At a population level, there is growing evidence of the beneficial effects of dietary flavonoids
on health. However, there is extensive heterogeneity in the response to increased intake …

Introduction Reporting and sharing pharmacogenetic test results across clinical laboratories
and electronic health records is a crucial step toward the implementation of clinical …

In 2009, the Clinical Pharmacogenetics Implementation Consortium (CPIC, www. cpicpgx.
org), a shared project between Pharmacogenomics Knowledge Base (PharmGKB …

Despite scientific and clinical advances in the field of pharmacogenomics (PGx), application
into routine care remains limited. Opportunely, several implementation studies and …

Both the Clinical Pharmacogenetics Implementation Consortium (CPIC) and Dutch
Pharmacogenetics Working Group provide therapeutic recommendations for well‐known …

The best-known role of UDP-glucuronosyltransferase enzymes (UGTs) in cancer is the
metabolic inactivation of drug therapies. By conjugating glucuronic acid to lipophilic drugs …

Safe and effective use of drugs requires an understanding of metabolism and transport. We
identified the 100 most prescribed drugs in six countries and conducted a literature search …

Purpose Existing pharmacogenomic informatics models, key implementation steps, and
emerging resources to facilitate the development of pharmacogenomic clinical decision …