Heat shock proteins are essential molecular chaperones that play crucial roles in stabilizing
protein structures, facilitating the repair or degradation of damaged proteins, and …

Mortalin (GRP75, HSPA9A), a heat shock protein (HSP), regulates a wide range of cellular
processes, including cell survival, growth, and metabolism. The regulatory functions of …

Functional inactivation of wild-type p53 is a major trait of cancerous cells. In many cases,
such inactivation occurs by either TP53 gene mutations or due to overexpression of p53 …

A class of chaperones dubbed heat shock protein 70 (Hsp70) possesses high relevance in
cancer diseases due to its cooperative activity with the well-established anticancer target …

Hypoxia‐inducible factor‐1, a heterodimer of alpha (HIF‐1α) and beta (HIF‐1β or ARNT)
subunits, is a major regulator of the transcriptional response to hypoxia. However, HIF‐1α …

The pro-oncogenic activities of estrogen receptor alpha (ERα) drive breast cancer
pathogenesis. Endocrine therapies that impair the production of estrogen or the action of the …

Simple Summary Mortalin is a heat shock protein 70 stress chaperone family member with
variable subcellular localization in normal and cancer cells. It is an essential protein with …

Long non-coding RNAs (lncRNAs) are versatile RNAs that regulate various cellular
processes, such as gene regulation, by acting as signals, decoys, guides, and scaffolds. A …

Prostate cancer (PC) is a major global health concern affecting male individuals. Among its
variants, androgen-independent prostate cancer exhibits slow progression and lacks …

Cancer poses a serious threat to human health and overall well-being. Conventional cancer
treatments predominantly encompass surgical procedures and radiotherapy. Nevertheless …