Development and scalable production of Newcastle disease virus-vectored vaccines for human and veterinary use

JPC Fulber, AA Kamen - Viruses, 2022 - mdpi.com
The COVID-19 pandemic has highlighted the need for efficient vaccine platforms that can
rapidly be developed and manufactured on a large scale to immunize the population against …

Development and evaluation of Newcastle disease-avian influenza bivalent vector vaccines in commercial chickens

Q Wu, L Wei, X Du, W Sun, S Li, X Guo, M Jiang… - International …, 2023 - Elsevier
Avian influenza (AI) and Newcastle disease (ND) are regarded as the leading viral infectious
diseases affecting the global poultry industry. Vaccination is a successful therapeutic …

Combining vascular normalization with an oncolytic virus enhances immunotherapy in a preclinical model of advanced-stage ovarian cancer

K Matuszewska, LA Santry, JP van Vloten… - Clinical Cancer …, 2019 - AACR
Purpose: Intravenous delivery of oncolytic viruses often leads to tumor vascular shutdown,
resulting in decreased tumor perfusion and elevated tumor hypoxia. We hypothesized that …

The downstream bioprocess toolbox for therapeutic viral vectors

R Kilgore, A Minzoni, S Shastry, W Smith… - … of Chromatography A, 2023 - Elsevier
Viral vectors are poised to acquire a prominent position in modern medicine and
biotechnology owing to their role as delivery agents for gene therapies, oncolytic agents …

Use of precision-cut lung slices as an ex vivo tool for evaluating viruses and viral vectors for gene and oncolytic therapy

MCR Gerpe, JP van Vloten, LA Santry, J de Jong… - … therapy Methods & …, 2018 - cell.com
Organotypic slice cultures recapitulate many features of an intact organ, including cellular
architecture, microenvironment, and polarity, making them an ideal tool for the ex vivo study …

Evaluation of the in vitro and in vivo effect of liposomal doxorubicin along with oncolytic Newcastle disease virus on 4T1 cell line: Animal preclinical research

P Faranoush, A Jahandideh… - Veterinary Medicine …, 2023 - Wiley Online Library
Background Breast cancer is one of the most common malignancies in women, with one in
20 globally. Oncolytic viruses have recently been the first step in the biological treatment of …

The human ACE-2 receptor binding domain of SARS-CoV-2 express on the viral surface of the Newcastle disease virus as a non-replicating viral vector vaccine …

BK Jung, YH An, JJ Jang, JH Jeon, SH Jang, H Jang - PloS one, 2022 - journals.plos.org
Since the SARS-CoV-2 infection was identified in December 2019, SARS-CoV-2 infection
has rapidly spread worldwide and has become a significant pandemic disease. In addition …

CD44 targeted delivery of oncolytic Newcastle disease virus encapsulated in thiolated Chitosan for sustained release in cervical cancer: a targeted immunotherapy …

K Kousar, F Naseer, MS Abduh, S Anjum… - Frontiers in …, 2023 - frontiersin.org
Introduction Cervical cancer accounts for one of most common cancers among women of
reproductive age. Oncolytic virotherapy has emerged as a promising immunotherapy …

Intranasal vaccination with a Newcastle disease virus-vectored vaccine protects hamsters from SARS-CoV-2 infection and disease

BM Warner, LA Santry, A Leacy, M Chan, PH Pham… - IScience, 2021 - cell.com
The pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause
of coronavirus disease 2019 (COVID-19). Worldwide efforts are being made to develop …

Combining vanadyl sulfate with Newcastle disease virus potentiates rapid innate immune-mediated regression with curative potential in murine cancer models

TM McAusland, JP van Vloten, LA Santry… - Molecular Therapy …, 2021 - cell.com
The avian paramyxovirus, Newcastle disease virus (NDV), is a promising oncolytic agent
that has been shown to be safe and effective in a variety of pre-clinical cancer models and …