Goblet cells (GCs) are specialized epithelial cells that line multiple mucosal surfaces and
have a well-appreciated role in barrier maintenance through the secretion of mucus …

Acute and chronic inflammatory diseases of the intestine impart a significant and negative
impact on the health and well-being of human and non-human mammalian animals …

Colon mucus segregates the intestinal microbiota from host tissues, but how it organizes to
function throughout the colon is unclear. In mice, we found that colon mucus consists of two …

Goblet cells and their main secretory product, mucus, play crucial roles in orchestrating the
colonic host-microbe interactions that help maintain gut homeostasis. However, the precise …

The intestinal mucosal barrier controlling the resident microbiome is dependent on a
protective mucus layer generated by goblet cells, impairment of which is a hallmark of the …

Mucus production by goblet cells of the large intestine serves as a crucial antimicrobial
protective mechanism at the interface between the eukaryotic and prokaryotic cells of the …

Despite recent advances in our understanding of the pathogenesis of attaching and effacing
(A/E) Escherichia coli infections, the mechanisms by which the host defends against these …

Antibiotics are often used in the clinic to treat bacterial infections, but the effects of these
drugs on microbiota composition and on intestinal immunity are poorly understood …

The objective of the present study was to evaluate the effects of fibre source on intestinal
mucosal barrier function in weaning piglets. A total of 125 piglets were randomly allotted on …

The CX3C chemokine family is composed of only one member, CX3CL1, also known as
fractalkine, which in mice is the sole ligand of the G protein-coupled, 7-transmembrane …