The Antimicrobial Potential of the Neem Tree Azadirachta indica
MR Wylie, DS Merrell - Frontiers in pharmacology, 2022 - frontiersin.org
Azadirachta indica (A. Juss), also known as the neem tree, has been used for millennia as a
traditional remedy for a multitude of human ailments. Also recognized around the world as a …
traditional remedy for a multitude of human ailments. Also recognized around the world as a …
Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …
[HTML][HTML] Identification of bioactive molecules from Triphala (Ayurvedic herbal formulation) as potential inhibitors of SARS-CoV-2 main protease (Mpro) through …
Severe acute respiratory syndrome coronavirus disease (SARS-CoV-2) induced coronavirus
disease 2019 (COVID-19) pandemic is the present worldwide health emergency. The global …
disease 2019 (COVID-19) pandemic is the present worldwide health emergency. The global …
Antibacterial potency of cytocompatible chitosan-decorated biogenic silver nanoparticles and molecular insights towards cell-particle interaction
In the study, leaf extract of Carica papaya was utilized for the biogenic fabrication process of
chitosan functionalized silver nanoparticles (Ag-Chito NPs). HRTEM analysis revealed that …
chitosan functionalized silver nanoparticles (Ag-Chito NPs). HRTEM analysis revealed that …
A strategy for screening novel umami dipeptides based on common feature pharmacophore and molecular docking
Y Xiong, X Gao, D Pan, T Zhang, L Qi, N Wang, Y Zhao… - Biomaterials, 2022 - Elsevier
To shorten the complex and tedious process of traditional umami peptide identification, a
novel model based on common feature pharmacophore (HipHop, a ligand molecule-based …
novel model based on common feature pharmacophore (HipHop, a ligand molecule-based …
Molecular interactions of tannic acid with proteins associated with SARS-CoV-2 infectivity
M Haddad, R Gaudreault, G Sasseville… - International journal of …, 2022 - mdpi.com
The overall impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on
our society is unprecedented. The identification of small natural ligands that could prevent …
our society is unprecedented. The identification of small natural ligands that could prevent …
Deciphering the binding mechanism of inhibitors of the SARS-CoV-2 main protease through multiple replica accelerated molecular dynamics simulations and free …
M Li, X Liu, S Zhang, S Liang, Q Zhang… - Physical Chemistry …, 2022 - pubs.rsc.org
The pneumonia outbreak caused by the SARS-CoV-2 virus poses a serious threat to human
health and the world economy. The development of safe and highly effective antiviral drugs …
health and the world economy. The development of safe and highly effective antiviral drugs …
Docking covalent targets for drug discovery: stimulating the computer-aided drug design community of possible pitfalls and erroneous practices
The continuous approval of covalent drugs in recent years for the treatment of diseases has
led to an increased search for covalent agents by medicinal chemists and computational …
led to an increased search for covalent agents by medicinal chemists and computational …
[HTML][HTML] Identification of INFG/STAT1/NOTCH3 as γ-Mangostin's potential targets for overcoming doxorubicin resistance and reducing cancer-associated fibroblasts in …
B Lawal, ATH Wu, CH Chen, TA George… - Biomedicine & …, 2023 - Elsevier
Triple-negative breast cancer (TNBC) is a very aggressive subtype of breast cancer
characterized by drug resistance and distant metastasis. Cancer stem cells (CSCs) are …
characterized by drug resistance and distant metastasis. Cancer stem cells (CSCs) are …
A novel immune checkpoint siglec-15 antibody inhibits LUAD by modulating mφ polarization in TME
X Xiao, Y Peng, Z Wang, L Zhang, T Yang, Y Sun… - Pharmacological …, 2022 - Elsevier
Abstract Background Siglec-15 (S15) is a type-I transmembrane protein and is considered a
new candidate of immune checkpoint inhibitor for cancer immunotherapy. Methods In the …
new candidate of immune checkpoint inhibitor for cancer immunotherapy. Methods In the …