Function of Drosophila Synaptotagmins in membrane trafficking at synapses

MC Quiñones-Frías, JT Littleton - Cellular and Molecular Life Sciences, 2021 - Springer
The Synaptotagmin (SYT) family of proteins play key roles in regulating membrane
trafficking at neuronal synapses. Using both Ca 2+-dependent and Ca 2+-independent …

Blood-brain barrier penetrating luminescent conjugates based on cyclometalated platinum (II) complexes

AI Solomatina, AD Slobodina, EV Ryabova… - Bioconjugate …, 2020 - ACS Publications
Herein we report on the synthesis, structural characterization and photophysical properties
of cyclometalated Pt (II) complexes [Pt (N^ C)(PPh2 (C6H4COOH)) Cl](where N^ C ligands …

Animal models of Alzheimer's disease

M Newman, D Kretzschmar, I Khan, M Chen… - Animal models for the …, 2017 - Elsevier
Alzheimer's disease is a major and increasing burden on families, communities, and
national health budgets. Despite intensive and extended research there is still widespread …

Mapping pathogenic processes contributing to neurodegeneration in Drosophila models of Alzheimer's disease

L Bergkvist, Z Du, G Elovsson, H Appelqvist… - FEBS Open …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people
and currently lacking available disease‐modifying treatments. Appropriate disease models …

Human APP Gene Expression Alters Active Zone Distribution and Spontaneous Neurotransmitter Release at the Drosophila Larval Neuromuscular Junction

EA Saburova, AN Vasiliev, VV Kravtsova… - Neural …, 2017 - Wiley Online Library
This study provides further insight into the molecular mechanisms that control
neurotransmitter release. Experiments were performed on larval neuromuscular junctions of …

[PDF][PDF] Mapping pathogenic processes contributing to neurodegeneration in Drosophila models of Alzheimer's

L Bergkvist, Z Du, G Elovsson, H Appelqvist, LS Itzhaki… - academia.edu
Alzheimer's disease is the most common neurodegenerative disease; thus, neuronal cell
death is a crucial feature of any potential AD animal model. By using the terminal …

[PDF][PDF] Распределение активных зон в нервно-мышечном синапсе личинки Drosophila melanogaster при экспрессии гена APP человека

ЕА Рагозина - core.ac.uk
Белок предшественник амилоида (APP, amyloid precursor protein) является крупным
трансмембранным белком, экспрессируемым в большинстве клеток животных. Долгое …

[PDF][PDF] Active zone distribution in the Drosophila larval neuromuscular junction under human APP gene expression

R Evgeniia - 2018 - dspace.spbu.ru
This study provides further insight into the molecular mechanisms that control
neurotransmitter release. Proteins that regulate vesicle exocytosis are localized at …

[引用][C] 淀粉样前体蛋白生理功能研究进展

吴琼, 温咪咪, 李娜, 姜春艳, 李韶 - 生理科学进展, 2016