The DNA of telomeres—the terminal DNA-protein complexes of chromosomes—differs
notably from other DNA sequences in both structure and function. Recent work has …

Subtelomeres are extraordinarily dynamic and variable regions near the ends of
chromosomes. They are defined by their unusual structure: patchworks of blocks that are …

The sequence of the human genome encodes the genetic instructions for human
physiology, as well as rich information about human evolution. In 2001, the International …

I have identified an activity in crude HeLa cell extracts that satlsfles the requirements for a
human telomere terminal transfemse or telomemse. It catalyzes the addition of a 6 …

To determine the evolutionary origin of the human telomere sequence (TTAGGG) n,
biotinylated oligodeoxynucleotides of this sequence were hybridized to metaphase spreads …

Yeast cells lacking a functional EST7 gene show progressive shortening of the terminal
GIs3T telomeric repeats and a parallel increase in the frequency of cell death. Although the …

The intrachromosomal distribution of non-telomeric sites of the (TTAGGG) n telomeric repeat
was determined for 100 vertebrate species. The most common non-telomeric location of this …

In yeast, telomere position effect (TPE) results in the reversible silencing of genes near
telomeres. Here we demonstrate the presence of TPE in human cells. HeLa clones …

We have identified two allelic genomic cosmids from human chromosome 2, c8. 1 and c29B,
each containing two inverted arrays of the vertebrate telomeric repeat in a head-to-head …

By using a fluorescence in situ hybridization technique we revealed that for nine different q-
arm telomere markers the positioning of chromosomes in human G 1 interphase nuclei was …