Normal eating behaviour is coordinated by the tightly regulated balance between intestinal
and extra-intestinal homeostatic and hedonic mechanisms. By contrast, food addiction is a …

Obesity continues to be among the top health concerns across the globe. Despite our failure
to contain the high prevalence of obesity, we now have a better understanding of its …

The efficacy of Roux-en-Y gastric-bypass (RYGB) and other bariatric surgeries in the
management of obesity and type 2 diabetes mellitus and novel developments in …

Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …

Obesity surgery remains the most effective treatment for obesity and its complications.
Weight loss was initially attributed to decreased energy absorption from the gut but has …

Because human energy metabolism evolved to favor adiposity over leanness, the
availability of palatable, easily attainable, and calorically dense foods has led to …

Can food be addictive? What does it mean to be a food addict? Do common underlying
neurobiological mechanisms contribute to drug and food addiction? These vexing questions …

Functional, molecular and genetic neuroimaging has highlighted the existence of brain
anomalies and neural vulnerability factors related to obesity and eating disorders such as …

The clinical efficacy of bariatric surgery has encouraged the scientific investigation of the gut
as a major endocrine organ. Manipulation of gastrointestinal anatomy through surgery has …

Recent progress in unravelling the nutrient-sensing mechanisms in the taste buds of the
tongue has triggered studies on the existence and role of chemosensory cells in the gut …