Glutamate is the most abundant free amino acid in the brain and is at the crossroad between
multiple metabolic pathways. Considering this, it was a surprise to discover that glutamate …

Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

GLT-1 (EAAT2; slc1a2) is the major glutamate transporter in the brain, and is predominantly
expressed in astrocytes, but at lower levels also in excitatory terminals. We generated a …

The mammalian genome contains four genes encoding GABA transporters (GAT1, slc6a1;
GAT2, slc6a13; GAT3, slc6a11; BGT1, slc6a12) and five glutamate transporter genes …

Astrocytes in the brain form an intimately associated network with neurons. They respond to
neuronal activity and synaptically released glutamate by raising intracellular calcium …

Neither normal brain function nor the pathological processes involved in neurological
diseases can be adequately understood without knowledge of the release, uptake and …

It is widely believed that long-term depression (LTD) and its counterpart, long-term
potentiation (LTP), involve mechanisms that are crucial for learning and memory. However …

Astrocytes can release the excitatory transmitter glutamate which is capable of modulating
activity in nearby neurons. This astrocytic glutamate release can occur through six known …

In the last years, the classical view of glial cells (in particular of astrocytes) as a simple
supportive cell for neurons has been replaced by a new vision in which glial cells are active …

The pathogenesis of Huntington's disease is still not completely understood. Several lines of
evidence from toxic/non‐transgenic animal models of Huntington's disease suggest that …