B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

Clones are the fundamental building blocks of immune repertoires. The number of different
clones relates to the diversity of the repertoire, whereas their size and sequence diversity …

Abs are immune system proteins that recognize noxious molecules for elimination. Their
sequence diversity and binding versatility have made Abs the primary class of …

Nearly all chronic human infections are associated with alterations in the memory B cell
(MBC) compartment, including a large expansion of CD19hiT-bethi MBC in the peripheral …

The poor efficacy of seasonal influenza virus vaccines is often attributed to pre-existing
immunity interfering with the persistence and maturation of vaccine-induced B cell …

The naïve antibody/B-cell receptor (BCR) repertoires of different individuals ought to exhibit
significant functional commonality, given that most pathogens trigger an effective antibody …

The diversity of antibody variable regions makes cDNA sequencing challenging, and
conventional monoclonal antibody cDNA amplification requires the use of degenerate …

Myasthenia gravis (MG) is a chronic autoimmune disorder characterized by muscle
weakness and caused by pathogenic autoantibodies that bind to membrane proteins at the …

Efficacy evaluation through human trials is crucial for advancing a vaccine candidate to
clinics. Next-generation sequencing (NGS) can be used to quantify B cell repertoire …

The human immunoglobulin repertoire is a hugely diverse set of sequences that are formed
by processes of gene rearrangement, heavy and light chain gene assortment, class …