Cyclobutanes are increasingly used in medicinal chemistry in the search for relevant
biological properties. Important characteristics of the cyclobutane ring include its unique …

The ɛ4 allele of the apolipoprotein E gene (APOE), which translates to the APOE4 isoform,
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …

Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism,
neurobiology, and neurodegenerative diseases. It has three major isoforms (apoE2, apoE3 …

First recognized as a major determinant in lipoprotein metabolism and cardiovascular
disease, apolipoprotein (apo) E has emerged as an important molecule in several biological …

Inflammation is a defense reaction against diverse insults, designed to remove noxious
agents and to inhibit their detrimental effects. It consists of a dazzling array of molecular and …

PURPOSE: The accumulation of numerous or confluent drusen, especially in the macula, is
a significant risk factor for the development of age-related macular degeneration (AMD) …

Alzheimer disease is a progressive dementia with unknown etiology that affects a growing
number of the aging population. Increased expression of inflammatory mediators in …

Neurotoxic amyloid β peptide (Aβ) accumulates in the brains of individuals with Alzheimer
disease (AD). The APOE4 allele is a major risk factor for sporadic AD and has been …

The premise of this review is that apolipoprotein (apo) E4 is much more than a contributing
factor to neurodegeneration. ApoE has critical functions in redistributing lipids among CNS …

Genetic variation influences gene expression, and this variation in gene expression can be
efficiently mapped to specific genomic regions and variants. Here we have used gene …