The potential of flavonoids and flavonoid metabolites in the treatment of neurodegenerative pathology in disorders of cognitive decline

J Melrose - Antioxidants, 2023 - mdpi.com
Flavonoids are a biodiverse family of dietary compounds that have antioxidant, anti-
inflammatory, antiviral, and antibacterial cell protective profiles. They have received …

Neuroprotective potentials of flavonoids: Experimental studies and mechanisms of action

P Bellavite - Antioxidants, 2023 - mdpi.com
Neurological and neurodegenerative diseases, particularly those related to aging, are on
the rise, but drug therapies are rarely curative. Functional disorders and the organic …

Recent advances in the biosynthesis, bioavailability, toxicology, pharmacology, and controlled release of citrus neohesperidin

S Akhter, MSI Arman, MA Tayab… - Critical Reviews in …, 2024 - Taylor & Francis
Abstract Neohesperidin (hesperetin 7-O-neohesperidoside), a well-known flavanone
glycoside widely found in citrus fruits, exhibits a variety of biological activities, with potential …

Multi-target-directed therapeutic strategies for Alzheimer's disease: controlling amyloid-β aggregation, metal ion homeostasis, and enzyme inhibition

J Yoo, J Lee, B Ahn, J Han, MH Lim - Chemical Science, 2025 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative dementia, marked by
progressive cognitive decline and memory impairment. Despite advances in therapeutic …

[HTML][HTML] Natural and semi-synthetic flavonoid anti-SARS-CoV-2 agents for the treatment of long COVID-19 disease and neurodegenerative disorders of cognitive …

J Melrose, MM Smith - Frontiers in Bioscience-Elite, 2022 - imrpress.com
The aim of this review is to highlight the beneficial attributes of flavonoids, a diverse family of
widely-distributed polyphenolic phytochemicals that have beneficial cell and tissue …

Neohesperidin Attenuates DSS-Induced Ulcerative Colitis by Inhibiting Inflammation, Reducing Intestinal Barrier Damage, and Modulating Intestinal Flora …

T Ju, Z Song, D Qin, J Cheng, T Li… - Journal of Agricultural …, 2024 - ACS Publications
Flavonoid natural products are emerging as a promising approach for treating Ulcerative
Colitis (UC) due to their natural origin and minimal toxicity. This study investigates the effects …

Imidazoles as Serotonin Receptor Modulators for Treatment of Depression: Structural Insights and Structure–Activity Relationship Studies

KK Goel, S Thapliyal, R Kharb, G Joshi, A Negi… - Pharmaceutics, 2023 - mdpi.com
Serotoninergic signaling is identified as a crucial player in psychiatric disorders (notably
depression), presenting it as a significant therapeutic target for treating such conditions …

Flavonoids with potential anti-amyloidogenic effects as therapeutic drugs for treating Alzheimer's disease

Q Wang, X Dong, R Zhang… - Journal of Alzheimer's …, 2021 - content.iospress.com
Alzheimer's disease (AD) is a central neurodegenerative disease generally among the
elderly; it accounts for approximately 50–75% of total cases of dementia patients and poses …

Chemical characterization and metabolic profiling of Xiao-Er-An-Shen Decoction by UPLC-QTOF/MS

R Yang, L Wei, J Wang, S Huang, P Mo… - Frontiers in …, 2023 - frontiersin.org
Background: Xiao-Er-An-Shen decoction (XEASD), a TCM formula composed of sixteen
Chinese medicinal herbs, has been used to alleviate tic disorders (TD) in clinical practice for …

Untargeted metabolomics unravels the effects of ginkgolide B-producing Lactiplantibacillus plantarum and co-induced fermentation of ginkgo kernel juice and their …

AP Bassey, Y Zhang, H Wu, J Yang, Y Zhu, S Xie… - Food Research …, 2024 - Elsevier
The objective of this study was to investigate the fermentation mechanism of ginkgo kernel
juice (GKJ) under unfermented (Group A), Ginkgolide B (GB)-producing Lactiplantibacillus …