Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update

K Laxmikeshav, P Kumari… - Medicinal Research …, 2022 - Wiley Online Library
This review article proposes a comprehensive report of the design strategies engaged in the
development of various sulfur‐bearing cytotoxic agents. The outcomes of various studies …

Comprehensive metabolic profiling of Acantholimon caryophyllaceum using LC–HRMS and evaluation of antioxidant activities, enzyme inhibition properties and …

H Kiziltas, Z Bingol, AC Goren, SM Pinar… - South African Journal of …, 2022 - Elsevier
The Acantholimon taxon consists of thorny, perennial and subshrub flowering plants.
Extraction of various Acantholimon species are traditionally applied to treat liver disease and …

[HTML][HTML] New synthetic quinaldine conjugates: assessment of their anti-cholinesterase, anti-tyrosinase and cytotoxic activities, and molecular docking analysis

M Zayene, FK Algethami, HN Abdelhamid… - Arabian Journal of …, 2022 - Elsevier
Despite all the progress made to enrich the existing bank of drugs used to treat and cure
Alzheimer and cancer patients, there is still a need to research and develop new bioactive …

[HTML][HTML] Targeting disease with benzoxazoles: a comprehensive review of recent developments

A Abdullahi, KY Yeong - Medicinal Chemistry Research, 2024 - Springer
Benzoxazole is an attractive scaffold in medicinal chemistry due to its diverse biological
applications. From 2016 to 2023, a plethora of benzoxazole derivatives have been …

[HTML][HTML] Cholinesterases inhibition, anticancer and antioxidant activity of novel benzoxazole and naphthoxazole analogs

A Skrzypek, M Karpińska, M Juszczak, A Grabarska… - Molecules, 2022 - mdpi.com
Benzoxazole and naphthoxazole fused systems are found in many biologically active
molecules. Novel benzoxazole and naphthoxazole analogs functionalized by the 2, 4 …

Synthesis, in vitro and docking studies of 2-substituted 5, 6, 7, 8-tetrahydrobenzo [4, 5] thieno [2, 3-d] pyrimidine-4 (3H)-one derivatives as agents for the treatment of …

AS Chiriapkin, IP Kodonidi, DI Pozdnyakov… - Chimica Techno …, 2022 - journals.urfu.ru
Alzheimer's disease is a chronic neurodegenerative disease, which is characterized mainly
by a progressive decrease in intellectual abilities, memory impairment and a change in a …

Binding mechanism between acetylcholinesterase and drugs pazopanib and lapatinib: biochemical and biophysical studies

T Meira Menezes, C Assis… - ACS Chemical …, 2021 - ACS Publications
Tyrosine kinase inhibitors (TKIs) are antitumor compounds that prevent the phosphorylation
of proteins in a biological environment. However, the multitarget performance of TKIs …

[HTML][HTML] Structural isomerism and enhanced lipophilicity of pyrithione ligands of organoruthenium (II) complexes increase inhibition on AChE and BuChE

J Kladnik, S Ristovski, J Kljun, A Defant… - International journal of …, 2020 - mdpi.com
The increasing number of Alzheimer's disease (AD) cases requires the development of new
improved drug candidates, possessing the ability of more efficient treatment as well as less …

[PDF][PDF] Synthesis and QSAR of new azomethine derivatives as agents for the treatment of Alzheimer's disease

AS Chiriapkin, IP Kodonidi, DI Pozdnyakov… - …, 2021 - researchgate.net
Alzheimer's disease is a chronic neurodegenerative disease with a high risk of social
maladaptation. The number of cases of the disease is constantly increasing, which, with a …

Synthesis of new pyrido[3,2-b][1,4]benzoxazines and -benzothiazines

AM Starosotnikov, VV Ivanova, TA Klimova… - Russian Chemical …, 2022 - Springer
Abstract New pyrido [3, 2-b][1, 4] benzoxazines and pyrido [3, 2-b][1, 4] benzothiazines were
synthesized by the base-mediated reactions of substituted 2-chloro-3-nitropyridines with o …