Progress in the mechanism and targeted drug therapy for COPD
C Wang, J Zhou, J Wang, S Li, A Fukunaga… - … and Targeted Therapy, 2020 - nature.com
Chronic obstructive pulmonary disease (COPD) is emphysema and/or chronic bronchitis
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …
Role of inflammatory cells in airway remodeling in COPD
Y Wang, J Xu, Y Meng, IM Adcock… - International journal of …, 2018 - Taylor & Francis
COPD is characterized by chronic bronchitis, chronic airway obstruction, and emphysema,
leading to a progressive and irreversible decline in lung function. Inflammation is central for …
leading to a progressive and irreversible decline in lung function. Inflammation is central for …
Matrix metalloproteinases in chronic obstructive pulmonary disease
ME Christopoulou, E Papakonstantinou… - International Journal of …, 2023 - mdpi.com
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade proteins of the
extracellular matrix and the basement membrane. Thus, these enzymes regulate airway …
extracellular matrix and the basement membrane. Thus, these enzymes regulate airway …
Matrix metalloproteinases in emphysema
Several studies have implicated a causative role for specific matrix metalloproteinases
(MMPs) in the development and progression of cigarette smoke-induced chronic obstructive …
(MMPs) in the development and progression of cigarette smoke-induced chronic obstructive …
[HTML][HTML] Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene
JM Wells, MM Parker, RA Oster, RP Bowler… - JCI insight, 2018 - ncbi.nlm.nih.gov
BACKGROUND. Matrix metalloprotease 9 (MMP-9) is associated with inflammation and lung
remodeling in chronic obstructive pulmonary disease (COPD). We hypothesized that …
remodeling in chronic obstructive pulmonary disease (COPD). We hypothesized that …
Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD
Background Matrix metalloproteinases (MMPs) are proteolytic enzymes that can degrade
the extracellular matrix and drive tissue remodelling, key processes in the pathogenesis of …
the extracellular matrix and drive tissue remodelling, key processes in the pathogenesis of …
Matrix metalloproteinases and their inhibitors in chronic obstructive pulmonary disease
Z Navratilova, V Kolek, M Petrek - Archivum immunologiae et therapiae …, 2016 - Springer
Chronic obstructive pulmonary disease (COPD) is characterised by irreversible airflow
limitation associated with chronic inflammation. Matrix metalloproteinases (MMPs) are …
limitation associated with chronic inflammation. Matrix metalloproteinases (MMPs) are …
The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity
S Dimic-Janjic, MA Hoda, B Milenkovic… - European journal of …, 2023 - Springer
Background Inflammation, oxidative stress and an imbalance between proteases and
protease inhibitors are recognized pathophysiological features of chronic obstructive …
protease inhibitors are recognized pathophysiological features of chronic obstructive …
[HTML][HTML] Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
There are no therapies to prevent emphysema progression. Chymotrypsin-like elastase 1
(CELA1) is a serine protease that binds and cleaves lung elastin in a stretch-dependent …
(CELA1) is a serine protease that binds and cleaves lung elastin in a stretch-dependent …
Present and future utility of computed tomography scanning in the assessment and management of COPD
K Ostridge, TMA Wilkinson - European Respiratory Journal, 2016 - Eur Respiratory Soc
Computed tomography (CT) is the modality of choice for imaging the thorax and lung
structure. In chronic obstructive pulmonary disease (COPD), it used to recognise the key …
structure. In chronic obstructive pulmonary disease (COPD), it used to recognise the key …