Pharmacological approaches to mitigate neuroinflammation in Alzheimer's disease

MS Uddin, MT Kabir, A Al Mamun, GE Barreto… - International …, 2020 - Elsevier
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases
characterized by the formation of extracellular amyloid beta (Aβ) plaques and intracellular …

Targeting neuroinflammation as a therapeutic strategy for Alzheimer's disease: mechanisms, drug candidates, and new opportunities

WY Fu, X Wang, NY Ip - ACS chemical neuroscience, 2018 - ACS Publications
Alzheimer's disease is a progressive neurodegenerative disease, and its incidence is
expected to increase owing to the aging population worldwide. Current therapies merely …

Immune and inflammatory determinants underlying Alzheimer's disease pathology

JE Baulch, MM Acharya, S Agrawal… - Journal of neuroimmune …, 2020 - Springer
This study examines the link between peripheral immune changes in perpetuation of the
Alzheimer's disease (AD) neuropathology and cognitive deficits. Our research design using …

[HTML][HTML] Impact of IL-21-associated peripheral and brain crosstalk on the Alzheimer's disease neuropathology

S Agrawal, JE Baulch, S Madan, S Salah… - Cellular and Molecular …, 2022 - Springer
Alzheimer's disease (AD) is associated with dysregulated immune and inflammatory
responses. Emerging evidence indicates that peripheral immune activation is linked to …

B Lymphocytes in Alzheimer's Disease—A Comprehensive Review

D Plantone, M Pardini, S Locci, F Nobili… - Journal of …, 2022 - content.iospress.com
Alzheimer's disease (AD) represents the most common type of neurodegenerative dementia
and is characterized by extracellular amyloid-β (Aβ) deposition, pathologic intracellular tau …

[HTML][HTML] IgM response against amyloid-beta in aging: a potential peripheral protective mechanism

S Agrawal, EM Abud, S Snigdha, A Agrawal - Alzheimer's Research & …, 2018 - Springer
Background The immune system plays a major role in the pathogenesis of age-related
dementia, including Alzheimer's disease (AD). An insight into age-associated changes in the …

Anti-α4β1 integrin antibodies attenuated brain inflammatory changes in a mouse model of Alzheimer's disease

G Manocha, A Ghatak, K Puig… - Current Alzheimer …, 2018 - ingentaconnect.com
Background: Alzheimer's disease (AD) is associated with age-associated central nervous
system degeneration and dementia. This decline in the function correlates with deposition of …

[HTML][HTML] Overview of immunotherapy in Alzheimer's disease (AD) and mechanisms of IVIG neuroprotection in preclinical models of AD

SE Counts, DK Lahiri - Current Alzheimer Research, 2014 - ncbi.nlm.nih.gov
Epidemiologic studies suggest that we are on the precipice of a worldwide epidemic of
Alzheimer's disease (AD), yet current treatment options are limited to short term symptomatic …

Concentrations of antibodies against β-amyloid 40/42 monomer and oligomers in Chinese intravenous immunoglobulins

S Ye, R Zeng, P Jiang, M Hou, F Liu, Z Wang… - … of Pharmaceutical and …, 2017 - Elsevier
Intravenous immunoglobulin (IVIg) preparations are being investigated as a potential agent
for treatment or prevention of Alzheimer's disease (AD). Antibodies towards soluble β …

[HTML][HTML] Demonstration of safety of intravenous immunoglobulin in geriatric patients in a long-term, placebo-controlled study of Alzheimer's disease

D Gelmont, RG Thomas, J Britt, JA Dyck-Jones… - Alzheimer's & Dementia …, 2016 - Elsevier
Introduction We present safety results from a study of Gammagard Liquid intravenous
immunoglobulin (IGIV) in patients with probable Alzheimer's disease. Methods This was a …