Introduction Dysfunction of the immune system is a hallmark of cancer. Through increased
understanding of the complex interactions between immunity and cancer, immunotherapy …

Abstract Purpose of Review Immune checkpoint therapy has dramatically changed the
therapeutic landscape of solid malignancies. Here, we review the scientific rationale and …

Purpose: This study aims to provide comprehensive insights into longitudinal immune
landscape in acute myeloid leukemia (AML) development and treatment, which may …

Background Patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) have
limited treatment options. In preclinical models of AML, inhibition of the PD‐1/PD‐L1 axis …

Immune surveillance mechanisms comprising of adaptive and innate immune systems are
naturally designed to eliminate AML development. However, leukemic cells apply various …

Chronic lymphocytic leukemia (CLL) is a malignancy of mature, antigen-experienced B
lymphocytes. Despite great progress recently achieved in the management of CLL, the …

Immune surveillance of incipient tumor cells is important for defense against cancer
development. However, active immune evasion is a cancer hallmark. 1 In acute myeloid …

Abstract Purpose of Review Acute myeloid leukaemia (AML) is a heterogeneous malignancy
for which treatment options remain suboptimal. It is clear that a greater understanding of the …

Tumors are not merely cancerous cells that undergo mindless proliferation. Rather, they are
highly organized and interconnected organ systems. Tumor cells reside in complex …

Simple Summary Bispecific T-cell engagers (BiTEs) and bispecific antibodies (BiAbs) have
emerged as novel therapeutic modalities in the treatment of advanced hematological …