Osteoarthritis is a common cause of disability worldwide. Although commonly referred to as
a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The …

Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage
degradation but also synovial membrane inflammation, osteophyte formation and …

Osteoarthritis (OA), one of the most common rheumatic disorders, is characterized by
cartilage breakdown and by synovial inflammation that is directly linked to clinical symptoms …

Objective To investigate the impact of systemic inhibition of interleukin 6 (IL-6) or signal
transducer and activator of transcription (Stat3) in an experimental model of osteoarthritis …

Obesity is widely acknowledged as a risk factor for both the incidence and progression of
osteoarthritis, and has a negative influence on outcomes. Loss of at least 10% of body …

OBJECTIVE: The role of inflammation in osteoarthritis (OA) pathogenesis is unclear, and the
associations between inflammatory cytokines and cartilage loss have not been reported. We …

The balance between bone forming cells (osteoblasts/osteocytes) and bone resorbing cells
(osteoclasts) plays a crucial role in tissue homeostasis and bone repair. Several hormones …

OBJECTIVES: Dental tissue disease and trauma provides an excellent model for the
interaction between tissue defence and regenerative processes and has application to many …

Proper development of the skeleton in utero and during growth requires mechanical
stimulation. Loading results in adaptive changes in bone that strengthen bone structure …

Objective To evaluate the efficacy of tocilizumab, an antibody against IL-6 receptor, in
patients with hand osteoarthritis. Methods This was a multicentre, 12-week, randomised …