Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

CBP/p300, functioning as histone acetyltransferases and transcriptional co-factors,
represents an attractive target for various diseases, including malignant tumor. The …

p300 acts as a transcription coactivator and an acetyltransferase that plays an important role
in tumourigenesis and progression. In previous studies, it has been confirmed that p300 is …

Lung cancer (LC) is a leading cause of death worldwide with high mortality and morbidity. A
wide variety of risk factors are considered for LC development such as smoking, air pollution …

Abstract CIC-DUX4 sarcoma (CDS) is a highly aggressive and metastatic small round type
of predominantly pediatric sarcoma driven by a fusion oncoprotein comprising the …

We examined the expression and the potential biological function of HBO1 in non-small cell
lung cancer (NSCLC). TCGA and Oncomine databases showed that HBO1 transcripts were …

Abstract p300/CBP histone acetyltransferases (HAT) are critical transcription coactivators
involved in multiple cellular activities. They act at multiple levels in non-small cell lung …

Adenoviral E1A binding protein p300 (EP300 or p300) and its similar paralog, cyclic-AMP
response element binding protein (CBP), are important histone acetyltransferases (HAT) …

Due to the contribution of highly homologous acetyltransferases CBP and p300 to
transcription elevation of oncogenes and other cancer promoting factors, these enzymes …

We have developed a novel bioorthogonal reaction that can selectively displace fluorine
substitutions alpha to amide bonds. This fluorine–thiol displacement reaction (FTDR) allows …