How does deep brain stimulation change the course of Parkinson's disease?

P Mahlknecht, T Foltynie, P Limousin… - Movement …, 2022 - Wiley Online Library
A robust body of evidence from randomized controlled trials has established the efficacy of
deep brain stimulation (DBS) in reducing off time and dyskinesias in levodopa‐treated …

Meta-analysis comparing deep brain stimulation of the globus pallidus and subthalamic nucleus to treat advanced Parkinson disease: a review

Y Liu, W Li, C Tan, X Liu, X Wang, Y Gui, L Qin… - Journal of …, 2014 - thejns.org
Object Deep brain stimulation (DBS) is the surgical procedure of choice for patients with
advanced Parkinson disease (PD). The globus pallidus internus (GPi) and the subthalamic …

Neurostimulation for Parkinson's disease with early motor complications

WMM Schuepbach, J Rau, K Knudsen… - … England Journal of …, 2013 - Mass Medical Soc
Background Subthalamic stimulation reduces motor disability and improves quality of life in
patients with advanced Parkinson's disease who have severe levodopa-induced motor …

Long-term outcomes (15 years) after subthalamic nucleus deep brain stimulation in patients with Parkinson disease

F Bove, D Mulas, F Cavallieri, A Castrioto… - Neurology, 2021 - AAN Enterprises
Objective To evaluate the effects of deep brain stimulation of the subthalamic nucleus (STN-
DBS) on motor complications in patients with Parkinson disease (PD) beyond 15 years after …

Optimal target localization for subthalamic stimulation in patients with Parkinson disease

ML Welter, M Schüpbach, V Czernecki, C Karachi… - Neurology, 2014 - AAN Enterprises
Objective: To further determine the causes of variable outcome from deep brain stimulation
of the subthalamic nucleus (DBS-STN) in patients with Parkinson disease (PD). Methods …

Quality of life predicts outcome of deep brain stimulation in early Parkinson disease

WMM Schuepbach, L Tonder, A Schnitzler, P Krack… - Neurology, 2019 - AAN Enterprises
Objective To investigate predictors for improvement of disease-specific quality of life (QOL)
after deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson disease …

Deep brain stimulation of the human reward system for major depression—rationale, outcomes and outlook

TE Schlaepfer, BH Bewernick, S Kayser… - …, 2014 - nature.com
Deep brain stimulation (DBS) as a putative approach for treatment-resistant depression
(TRD) has now been researched for about a decade. Several uncontrolled studies—all in …

Clinical outcome of deep brain stimulation for Parkinson's disease

G Deuschl, S Paschen, K Witt - Handbook of clinical neurology, 2013 - Elsevier
Deep brain stimulation is one of the most effective treatments of Parkinson's disease (PD).
This report summarizes the state of the art as at January 2013. Stimulation of the …

Patients' expectations of deep brain stimulation, and subjective perceived outcome related to clinical measures in Parkinson's disease: a mixed-method approach

F Maier, CJ Lewis, N Horstkoetter, C Eggers… - Journal of Neurology …, 2013 - jnnp.bmj.com
Objective To study patients' expectations of subthalamic deep brain stimulation (STN-DBS)
and their subjective perceived outcome, by using qualitative and quantitative methods in …

Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease

ST Jost, V Visser-Vandewalle, A Rizos… - npj Parkinson's …, 2021 - nature.com
To identify predictors of 36-month follow-up quality of life (QoL) outcome after bilateral
subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD). In this …