Atovaquone belongs to a naphthoquinone class of drugs and is used in combination with
proguanil (Malarone) for the treatment of acute, uncomplicated malaria caused by …

Malaria is a vector-borne parasitic disease caused by the apicomplexan protozoan parasite
Plasmodium. Malaria is a significant health problem and the leading cause of …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Control of parasite transmission is critical for the eradication of malaria. However, most
antimalarial drugs are not active against P. falciparum gametocytes, responsible for the …

Heat-shock proteins (hsps) have been identified as molecular chaperones conserved
between microbes and man and grouped by their molecular mass and high degree of amino …

To limit the spread and impact of anti-malarial drug resistance and react accordingly,
surveillance systems able to detect and track in real-time its emergence and spread need to …

Covering: 2005 to 2013In this review recent progress in the development of heat shock
proteins (Hsp90) in oncogenesis is illuminated. Particular emphasis is put on inhibitors such …

Abstract The kinetoplastids Leishmania major, Trypanosoma brucei and Trypanosoma cruzi
are causative agents of a diverse spectrum of human diseases: leishmaniasis, sleeping …

Interactions between antimicrobial agents provide clues as to their mechanisms of action
and influence the combinations chosen for therapy of infectious diseases. In the treatment of …

Plasmodium falciparum causes the most lethal and widespread form of malaria. Eradication
of malaria remains a priority due to the increasing number of cases of drug resistance. The …