Unlike other human cancers, in which all primary tumors arise de novo, ovarian epithelial
cancers are primarily imported from either endometrial or fallopian tube epithelium. The …

Ovarian cancer is the most lethal of all gynecologic malignancies and the eighth leading
cause of cancer-related deaths among women worldwide. The main reasons for this poor …

Ovarian cancer is the most lethal gynecologic malignancy, and patient prognosis has not
improved significantly over the last several decades. In order to improve therapeutic …

Proteases play a crucial role in the progression and metastasis of ovarian cancer.
Pericellular protein degradation and fragmentation along with remodeling of the …

MUC16 (the cancer antigen CA125) is the most commonly used serum biomarker in
epithelial ovarian cancer, with increasing levels reflecting disease progression. It is a …

Owing to technical advances in single-cell biology, the appreciation of cellular heterogeneity
has increased, which has aided our understanding of organ function, homeostasis, and …

Introduction Benign and precancerous endometrial hyperplasias (EH) are differentiated
according to two alternative histomorphologic classifications: World Health Organization …

High-grade serous ovarian cancer is a deadly disease that can originate from the fallopian
tube or the ovarian surface epithelium. The PAX (paired box) genes PAX2 and PAX8 are …

The epithelium lining the oviduct or fallopian tube consists of multiciliated and secretory
cells, which support fertilization and preimplantation development, however, its homeostasis …

This review focuses on the conventional treatment, signaling pathways and various reasons
for drug resistance with an understanding of novel methods that can lead to effective …