Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi

L Brown, JM Wolf, R Prados-Rosales… - Nature Reviews …, 2015 - nature.com
Extracellular vesicles (EVs) are produced by all domains of life. In Gram-negative bacteria,
EVs are produced by the pinching off of the outer membrane; however, how EVs escape the …

Exploring the Role of Staphylococcus aureus in Inflammatory Diseases

H Chen, J Zhang, Y He, Z Lv, Z Liang, J Chen, P Li… - Toxins, 2022 - mdpi.com
Staphylococcus aureus is a very common Gram-positive bacterium, and S. aureus infections
play an extremely important role in a variety of diseases. This paper describes the types of …

Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections

RA Proctor, C Von Eiff, BC Kahl, K Becker… - Nature Reviews …, 2006 - nature.com
Small colony variants constitute a slow-growing subpopulation of bacteria with distinctive
phenotypic and pathogenic traits. Phenotypically, small colony variants have a slow growth …

The role of the skin microbiome in atopic dermatitis

MR Williams, RL Gallo - Current allergy and asthma reports, 2015 - Springer
Atopic dermatitis (AD) is a common skin disease that affects a large proportion of the
population worldwide. The incidence of AD has increased over the last several decades …

Staphylococcus aureus Hemolysins, bi-component Leukocidins, and Cytolytic Peptides: A Redundant Arsenal of Membrane-Damaging Virulence Factors?

F Vandenesch, G Lina, T Henry - Frontiers in cellular and infection …, 2012 - frontiersin.org
One key aspect of the virulence of Staphylococcus aureus lies in its ability to target the host
cell membrane with a large number of membrane-damaging toxins and peptides. In this …

Intracellular Staphylococcus aureus: live-in and let die

M Fraunholz, B Sinha - Frontiers in cellular and infection microbiology, 2012 - frontiersin.org
Staphylococcus aureus uses a plethora of virulence factors to accommodate a diversity of
niches in its human host. Aside from the classical manifestations of S. aureus-induced …

Staphylococcus aureus α-Hemolysin Activates the NLRP3-Inflammasome in Human and Mouse Monocytic Cells

RR Craven, X Gao, IC Allen, D Gris, JB Wardenburg… - PloS one, 2009 - journals.plos.org
Community Acquired Methicillin Resistant Staphylococcus aureus (CA-MRSA) causes
severe necrotizing infections of the skin, soft tissues, and lungs. Staphylococcal α-hemolysin …

Endogenous stimulus-powered antibiotic release from nanoreactors for a combination therapy of bacterial infections

Y Wu, Z Song, H Wang, H Han - Nature communications, 2019 - nature.com
The use of an endogenous stimulus instead of external trigger has an advantage for
targeted and controlled release in drug delivery. Here, we report on cascade nanoreactors …

Helicobacter pylori VacA, a paradigm for toxin multifunctionality

TL Cover, SR Blanke - Nature Reviews Microbiology, 2005 - nature.com
Bacterial protein toxins alter eukaryotic cellular processes and enable bacteria to
successfully colonize their hosts. In recent years, there has been increased recognition that …

A Potential New Pathway for Staphylococcus aureus Dissemination: The Silent Survival of S. aureus Phagocytosed by Human Monocyte-Derived Macrophages

M Kubica, K Guzik, J Koziel, M Zarebski, W Richter… - PloS one, 2008 - journals.plos.org
Although considered to be an extracellular pathogen, Staphylococcus aureus is able to
invade a variety of mammalian, non-professional phagocytes and can also survive …