The thymus is the primary immune organ responsible for generating self‐tolerant and
immunocompetent T cells. However, the thymus gradually involutes during early life …

Biological sex differences refer to differences between males and females caused by the sex
chromosome complement (that is, XY or XX), reproductive tissues (that is, the presence of …

A mechanistic connection between aging and development is largely unexplored. Through
profiling age-related chromatin and transcriptional changes across 22 murine cell types …

The thymus is an intricate primary lymphoid organ, wherein bone marrow–derived lymphoid
progenitor cells are induced to develop into functionally competent T cells that express a …

Thymic epithelial cells (TECs) and hematopoietic antigen presenting cells (HAPCs) in the
thymus microenvironment provide essential signals to self-reactive thymocytes that induce …

Thymus is a primary lymphoid organ essential for the development of T lymphocytes. Age-
related thymic involution is a prominent feature of immune senescence. The thymus …

The capacity of T cells to recognize and mount an immune response against tumor antigens
depends on the large diversity of the T-cell receptor (TCR) repertoire generated in the …

Cellular senescence was first described as a physiological tumor cell suppressor
mechanism that leads to cell growth arrest with production of the senescence-associated …

Syringic acid (SA), a naturally occurring phenolic substance present in many edible plants
and fruits, has been shown to have potential in immunoenhancement applications. In this …

Vaccination has been shown to be the most effective means of preventing infectious
diseases, although older people commonly have a suboptimal immune response to …