Caloric restriction, be it constant or intermittent, is reputed to have health-promoting and
lifespan-extending effects. Caloric restriction mimetics (CRMs) are compounds that mimic …

Advanced age is a primary risk factor for female infertility due to reduced ovarian reserve
and declining oocyte quality. However, as an important contributing factor, the role of …

A fundamental tenet of inheritance in sexually reproducing organisms such as humans and
laboratory mice is that gametes combine randomly at fertilization, thereby ensuring a …

Liver fibrosis and hepatocellular carcinoma (HCC) have worldwide impact but continue to
lack safe, low cost, and effective treatments. In this study, we show how the simple …

Aging can be viewed as a quasi-programmed phenomenon driven by the overactivation of
the nutrient-sensing mTOR gerogene. mTOR-driven aging can be triggered or accelerated …

The exposure of calreticulin (CRT) on the surface of stressed and dying cancer cells
facilitates their uptake by dendritic cells and the subsequent presentation of tumor …

The naked mole-rat (Heterocephalus glaber) is characterized by a more than tenfold higher
life expectancy compared to another rodent species of the same size, namely, the laboratory …

Lifespan-extending interventions are generally thought to result in reduced fecundity. The
generality of this principle and how it may extend to nutrition and metabolism is not …

Simple Summary Reduced food intake significantly enhances healthy lifespan in both model
animals and humans, and decreases the incidence of cancer and other age-related …

Organisms adapt developmental and physiological features to local and transient conditions
in part by modulating transcription, translation, and protein functions, usually without …