Metabolic glycan labelling for cancer-targeted therapy
Metabolic glycoengineering with unnatural sugars provides a powerful tool to label cell
membranes with chemical tags for subsequent targeted conjugation of molecular cargos via …
membranes with chemical tags for subsequent targeted conjugation of molecular cargos via …
Chemical glycoproteomics
KK Palaniappan, CR Bertozzi - Chemical reviews, 2016 - ACS Publications
Chemical tools have accelerated progress in glycoscience, reducing experimental barriers
to studying protein glycosylation, the most widespread and complex form of posttranslational …
to studying protein glycosylation, the most widespread and complex form of posttranslational …
Selective in vivo metabolic cell-labeling-mediated cancer targeting
Distinguishing cancer cells from normal cells through surface receptors is vital for cancer
diagnosis and targeted therapy. Metabolic glycoengineering of unnatural sugars provides a …
diagnosis and targeted therapy. Metabolic glycoengineering of unnatural sugars provides a …
Cell membrane–camouflaged liposomes for tumor cell–selective glycans engineering and imaging in vivo
The dynamic change of cell-surface glycans is involved in diverse biological and
pathological events such as oncogenesis and metastasis. Despite tremendous efforts, it …
pathological events such as oncogenesis and metastasis. Despite tremendous efforts, it …
Recent advances in developing active targeting and multi-functional drug delivery systems via bioorthogonal chemistry
W Yi, P Xiao, X Liu, Z Zhao, X Sun, J Wang… - … and Targeted Therapy, 2022 - nature.com
Bioorthogonal chemistry reactions occur in physiological conditions without interfering with
normal physiological processes. Through metabolic engineering, bioorthogonal groups can …
normal physiological processes. Through metabolic engineering, bioorthogonal groups can …
Bioorthogonally activatable cyanine dye with torsion-induced disaggregation for in vivo tumor imaging
X Zhang, J Gao, Y Tang, J Yu, SS Liew, C Qiao… - Nature …, 2022 - nature.com
Advancement of bioorthogonal chemistry in molecular optical imaging lies in expanding the
repertoire of fluorophores that can undergo fluorescence signal changes upon …
repertoire of fluorophores that can undergo fluorescence signal changes upon …
Click chemistry as a tool for cell engineering and drug delivery
Y Takayama, K Kusamori, M Nishikawa - Molecules, 2019 - mdpi.com
Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins,
and other molecules, and has been used in many research fields because of its beneficial …
and other molecules, and has been used in many research fields because of its beneficial …
Glycan labeling and analysis in cells and in vivo
B Cheng, Q Tang, C Zhang… - Annual Review of …, 2021 - annualreviews.org
As one of the major types of biomacromolecules in the cell, glycans play essential functional
roles in various biological processes. Compared with proteins and nucleic acids, the …
roles in various biological processes. Compared with proteins and nucleic acids, the …
Cell-type-specific labeling and profiling of glycans in living mice
Metabolic labeling of glycans with clickable unnatural sugars has enabled glycan analysis in
multicellular systems. However, cell-type-specific labeling of glycans in vivo remains …
multicellular systems. However, cell-type-specific labeling of glycans in vivo remains …
A Nature‐Inspired Metal–Organic Framework Discriminator for Differential Diagnosis of Cancer Cell Subtypes
Metabolic glycan labeling (MGL) followed by bioorthogonal chemistry provides a powerful
tool for tumor imaging and therapy. However, selectively metabolic labeling of cells or …
tool for tumor imaging and therapy. However, selectively metabolic labeling of cells or …