Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1
J Düring, M Wolter, JJ Toplak, C Torres… - Nature Structural & …, 2024 - nature.com
Ubiquitin ligases (E3s) are pivotal specificity determinants in the ubiquitin system by
selecting substrates and decorating them with distinct ubiquitin signals. However, structure …
selecting substrates and decorating them with distinct ubiquitin signals. However, structure …
Masked cerulenin enables a dual-site selective protein crosslink
Protein-reactive natural products such as the fungal metabolite cerulenin are recognized for
their value as therapeutic candidates, due to their ability to selectively react with catalytic …
their value as therapeutic candidates, due to their ability to selectively react with catalytic …
The Kinetics of Carbon‐Carbon Bond Formation in Metazoan Fatty Acid Synthase and Its Impact on Product Fidelity
C Gusenda, AR Calixto, JR Da Silva… - Angewandte Chemie …, 2025 - Wiley Online Library
Fatty acid synthase (FAS) multienzymes are responsible for de novo fatty acid biosynthesis
and crucial in primary metabolism. Despite extensive research, the molecular details of the …
and crucial in primary metabolism. Despite extensive research, the molecular details of the …
Die Kinetik der Kohlenstoff‐Kohlenstoff‐Bindungsbildung in der metazoischen Fettsäure Synthase und ihr Einfluss auf die Produktgenauigkeit
C Gusenda, AR Calixto, JR Da Silva… - Angewandte …, 2025 - Wiley Online Library
Fettsäuresynthase (FAS)-Multienzyme sind verantwortlich für die De-novo-Biosynthese von
Fettsäuren und spielen eine wesentliche Rolle im Primärstoffwechsel. Trotz umfangreicher …
Fettsäuren und spielen eine wesentliche Rolle im Primärstoffwechsel. Trotz umfangreicher …
Mitochondrial Acyl Carrier Protein of Leishmania major Displays Features Distinct from the Canonical Type II ACP
Prokaryotes synthesize fatty acids using a type II synthesis pathway (FAS). In this process,
the central player, ie, the acyl carrier protein (ACP), sequesters the growing acyl chain in its …
the central player, ie, the acyl carrier protein (ACP), sequesters the growing acyl chain in its …
Screening of promising molecules against potential drug targets in Yersinia pestis by integrative pan and subtractive genomics, docking and simulation approach
L Chen, L Zhang, Y Li, L Qiao, S Kumar - Archives of Microbiology, 2024 - Springer
This study focuses on Yersinia pestis, the bacterium responsible for plague, which posed a
severe threat to public health in history. Despite the availability of antibiotics treatment, the …
severe threat to public health in history. Despite the availability of antibiotics treatment, the …