The ESCRT machinery consists of the peripheral membrane protein complexes ESCRT-0,-I,-
II,-III, and Vps4–Vta1, and the ALIX homodimer. The ESCRT system is required for …

Rabies virus, the prototypical neurotropic virus, causes one of the most lethal zoonotic
diseases. According to official estimates, over 55,000 people die of the disease annually, but …

Like other enveloped viruses, HIV-1 uses cellular machinery to bud from infected cells. We
now show that Tsg101 protein, which functions in vacuolar protein sorting (Vps), is required …

Retroviral Gag proteins encode sequences, termed late domains, which facilitate the final
stages of particle budding from the plasma membrane. We report here that interactions …

HIV-1 particle production occurs in a series of steps promoted by the viral Gag protein.
Although it is well established that assembly and release take place at the plasma …

Neuronal precursor cell-expressed developmentally downregulated 4 (Nedd4) is the
prototypical protein in a family of E3 ubiquitin ligases that have a common domain …

VP40, the putative matrix protein of both Ebola and Marburg viruses, possesses a conserved
proline-rich motif (PY motif) at its N terminus. We demonstrate that the VP40 protein can …

Plant viruses have evolved a wide array of strategies to ensure efficient transfer from one
host to the next. Any organism feeding on infected plants and traveling between plants can …

For influenza virus, we developed an efficient, noncytotoxic, plasmid-based virus-like
particle (VLP) system to reflect authentic virus particles. This system was characterized …

Domains have been identified in the Gag proteins of a number of retroviruses, and in the
matrix proteins of the rhabdoviruses and filoviruses, that play a critical role in the pinching off …