Sortases and the art of anchoring proteins to the envelopes of gram-positive bacteria

LA Marraffini, AC DeDent… - … and molecular biology …, 2006 - Am Soc Microbiol
The cell wall envelopes of gram-positive bacteria represent a surface organelle that not only
functions as a cytoskeletal element but also promotes interactions between bacteria and …

Molecular structure and function of the glycine receptor chloride channel

JW Lynch - Physiological reviews, 2004 - journals.physiology.org
The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

Emerging structure of the nicotinic acetylcholine receptors

A Karlin - Nature Reviews Neuroscience, 2002 - nature.com
The conversion of acetylcholine binding into ion conduction across the membrane is
becoming more clearly understood in terms of the structure of the receptor and its transitions …

Nicotinic receptors at the amino acid level

PJ Corringer, NL Novère… - Annual review of …, 2000 - annualreviews.org
nAChRs are pentameric transmembrane proteins into the superfamily of ligand-gated ion
channels that includes the 5HT3, glycine, GABAA, and GABAC receptors. Electron …

The structural basis of function in Cys-loop receptors

AJ Thompson, HA Lester… - Quarterly reviews of …, 2010 - cambridge.org
Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are
responsible for fast excitatory and inhibitory transmission in the peripheral and central …

Nicotinic acetylcholine receptors: from structure to brain function

RC Hogg, M Raggenbass, D Bertrand - Reviews of physiology …, 2003 - Springer
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels and can be
divided into two groups: muscle receptors, which are found at the skeletal neuromuscular …

[8] Substituted-cysteine accessibility method

A Karlin, MH Akabas - Methods in enzymology, 1998 - Elsevier
Publisher Summary The functional properties of ion channels, such as gating, ion selectivity,
single-channel conductance, multi-ion occupancy, transient blocking, desensitization, and …

Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins

A Karlin, MH Akabas - Neuron, 1995 - Elsevier
The nicotinic acetylcholine (ACh) receptors and the other neurotransmitter-gated ion
channels have key roles in fast synaptic transmission throughout the nervous system. These …

Cys-loop receptors: new twists and turns

HA Lester, MI Dibas, DS Dahan, JF Leite… - Trends in …, 2004 - cell.com
New hypotheses and predictions have arisen from recent work revealing atomic-scale or
near-atomic-scale structures of receptors in the 'Cys-loop'superfamily. How general is the …

Nicotinic acetylcholine receptors in health and disease

J Lindstrom - Molecular neurobiology, 1997 - Springer
Nicotinic acetylcholine receptors (AChRs) are a family of acetylcholine-gated cation
channels that form the predominant excitatory neurotransmitter receptors on muscles and …