The maintenance of genetic stability is of crucial importance for any form of life. Prior to cell
division in each mammalian cell, the process of DNA replication must faithfully duplicate the …

Three multi-subunit DNA polymerase enzymes lie at the heart of the chromosome replication
machinery in the eukaryotic cell nucleus. Through a combination of genetic, molecular …

In a number of families with colorectal adenomatous polyposis or suspected Lynch
syndrome/HNPCC, no germline alteration in the APC, MUTYH, or mismatch repair (MMR) …

Precise duplication of the human genome is challenging due to both its size and sequence
complexity. DNA polymerase errors made during replication, repair or recombination are …

The p12 subunit of polymerase delta (Pol δ) is degraded in response to DNA damage
induced by UV, alkylating agents, oxidative, and replication stresses. This leads to the …

Abstract Casein kinase 2 (CK2) is a highly conserved and ubiquitous eukaryotic Ser/Thr
protein kinase. Genetic, biochemical, and cell biological studies have indicated the …

SUMOylation is a form of post-translational modification involving covalent attachment of
SUMO (Small Ubiquitin-like Modifier) polypeptides to specific lysine residues in the target …

Human DNA polymerase delta (Polδ), a holoenzyme consisting of p125, p50, p68, and p12
subunits, plays an essential role in DNA replication, repair, and recombination. Herein …

DNA polymerase delta (Pol δ) is a central enzyme for eukaryotic DNA replication and repair.
Pol δ is a complex of four subunits p125, p68, p50, and p12. The functional properties of Pol …

DNA replication is a dynamic process that requires the precise coordination of numerous
cellular proteins. At the core of replication in eukaryotic cells are three DNA polymerases …