PURPOSE Evidence-based guidelines recommend cascade genetic counseling and testing
for hereditary cancer syndromes, providing relatives the opportunity for early detection and …

Hereditary cancer syndromes are inherited pathogenic genetic variants that significantly
increase the risk of developing cancer. When individuals become aware of their increased …

The uptake of genetic counseling and predictive genetic testing by family members at risk for
hereditary tumor syndromes is generally below 50%. To address this issue, a new guideline …

Low uptake of genetic services among members of families with hereditary breast and
ovarian cancer (HBOC) suggests limitations of proband-mediated communication of genetic …

Background We estimated the cost-effectiveness of universal DNA screening for Lynch
syndrome (LS) among newly diagnosed patients with colorectal cancer (CRC) followed by …

Whilst the finding of heritable susceptibility to disease was once relatively rare,
mainstreaming of genetic testing has resulted in a steady increase. Patients are often …

The public health impact of genomic screening can be enhanced by cascade testing.
However, cascade testing depends on communication of results to family members. While …

In the era of Precision Medicine the approach to disease diagnosis, treatment, and
prevention is being transformed across medical specialties, including Cardiology, and …

Background Inherited risk is a family issue. Identifying family members who carry a
pathogenic genetic variant that increases risk of cancers and other chronic diseases can be …

Background A theory-guided Tailored Counseling and Navigation (TCN) intervention
successfully increased cancer genetic risk assessment (CGRA) uptake among cancer …