Terpene synthases as metabolic gatekeepers in the evolution of plant terpenoid chemical diversity

PS Karunanithi, P Zerbe - Frontiers in plant science, 2019 - frontiersin.org
Terpenoids comprise tens of thousands of small molecule natural products that are widely
distributed across all domains of life. Plants produce by far the largest array of terpenoids …

Recent progress and new perspectives for diterpenoid biosynthesis in medicinal plants

Z Hu, X Liu, M Tian, Y Ma, B Jin, W Gao… - Medicinal Research …, 2021 - Wiley Online Library
Abstract Diterpenoids, including more than 18,000 compounds, represent an important class
of metabolites that encompass both phytohormones and some industrially relevant …

Engineering chimeric diterpene synthases and isoprenoid biosynthetic pathways enables high-level production of miltiradiene in yeast

T Hu, J Zhou, Y Tong, P Su, X Li, Y Liu, N Liu, X Wu… - Metabolic …, 2020 - Elsevier
Miltiradiene is a key intermediate in the biosynthesis of many important natural diterpene
compounds with significant pharmacological activity, including triptolide, tanshinones …

Tanshinones: Leading the way into Lamiaceae labdane-related diterpenoid biosynthesis

Z Wang, RJ Peters - Current opinion in plant biology, 2022 - Elsevier
Tanshinones are the bioactive diterpenoid constituents of the traditional Chinese medicinal
herb Danshen (Salvia miltiorrhiza), and are examples of the phenolic abietanes widely …

A database-driven approach identifies additional diterpene synthase activities in the mint family (Lamiaceae)

SR Johnson, WW Bhat, J Bibik, A Turmo… - Journal of Biological …, 2019 - ASBMB
Members of the mint family (Lamiaceae) accumulate a wide variety of industrially and
medicinally relevant diterpenes. We recently sequenced leaf transcriptomes from 48 …

Sequential Separation of Essential Oil Components during Hydrodistillation of Fresh Foliage from Azorean Cryptomeria japonica (Cupressaceae): Effects on …

F Arruda, A Lima, T Wortham, A Janeiro, T Rodrigues… - Plants, 2024 - mdpi.com
Cryptomeria japonica wood industry generates large amounts of foliage biomass residues.
Due to the increasing applications and markets for essential oils (EOs), fresh Azorean C …

From Functional Plasticity of Two Diterpene Synthases (IrTPS2/IrKSL3a) to Enzyme Evolution

B Jin, K Xu, J Guo, Y Ma, J Yang, N Chen, T Zeng… - ACS …, 2024 - ACS Publications
Terpenoids are an intriguing class of natural products with diverse structures and biological
activities whose complexity stems in large part from terpene synthases (TPSs). These …

A chromosome-level genome assembly reveals that tandem-duplicated CYP706V oxidase genes control oridonin biosynthesis in the shoot apex of Isodon rubescens

Y Sun, J Shao, H Liu, H Wang, G Wang, J Li, Y Mao… - Molecular Plant, 2023 - cell.com
The ent-kaurenoids (eg, oridonin and enmein) from the Isodon genus (Lamiaceae) are one
class of diterpenoids with rich structural diversity and intriguing pharmaceutical activity. In …

The foxtail millet (Setaria italica) terpene synthase gene family

PS Karunanithi, DI Berrios, S Wang, J Davis… - The Plant …, 2020 - Wiley Online Library
Terpenoid metabolism plays vital roles in stress defense and the environmental adaptation
of monocot crops. Here, we describe the identification of the terpene synthase (TPS) gene …

[HTML][HTML] Combinatorial biosynthesis in yeast leads to over 200 diterpenoids

M Frey, U Bathe, L Meink, GU Balcke, J Schmidt… - Metabolic …, 2024 - Elsevier
Diterpenoids form a diverse group of natural products, many of which are or could become
pharmaceuticals or industrial chemicals. The modular character of diterpene biosynthesis …